Combined preoperative use of celecoxib and gabapentin in the management of postoperative pain

Aesthetic Plastic Surgery
Alan A ParsaF Don Parsa

Abstract

In 2005 we reported a study on the efficacy of the preoperative use of the selective COX-2 inhibitor celecoxib (Celebrex) for reducing both postoperative pain and opioid requirements in patients undergoing bilateral subpectoral breast augmentation. Our findings showed that patients who received 400 mg of celecoxib 30 min before surgery required significantly less postoperative opioid analgesics compared with those given a placebo. Gabapentin (Neurontin) is an agent commonly used to control neuropathic pain. Here we describe a prospective study assessing the efficacy of preoperative gabapentin in combination with celecoxib for reducing postoperative pain and opioid requirements in elective subpectoral breast augmentation. One hundred eighteen patients were given 1200 mg of gabapentin and 400 mg of celecoxib 30-60 min before surgery. From the day of surgery until postoperative day 5, patients documented any use of analgesics and recorded their degree of pain. Results were then compared with those of our previous study in which only celecoxib was used. The combination of gabapentin and celecoxib was found to be significantly superior (p < 0.001) in reducing postoperative pain and opioid requirements than celecoxib alone in the man...Continue Reading

References

Apr 29, 1998·Epilepsy Research·C P TaylorL Singh
Jul 28, 1999·Anesthesiology·D R SinclairG Mezei
Feb 16, 2000·Neurobiology of Aging·L Gagliese, R Melzack
Jun 10, 2000·Science·C J Woolf, M W Salter
Apr 18, 2001·Molecular Pharmacology·E MaraisF Hofmann
Jul 24, 2001·Anesthesiology·C J Woolf, M B Max
Sep 28, 2002·Anesthesia and Analgesia·Argyro FassoulakiQuinn Hogan
Oct 10, 2002·Regional Anesthesia and Pain Medicine·Margaret BoneDonal J Buggy
Oct 31, 2002·Nature Neuroscience·Joachim Scholz, Clifford J Woolf
Jun 14, 2003·European Journal of Anaesthesiology·B KaramanlioğluN Süt
Nov 5, 2003·British Journal of Pharmacology·Garth T WhitesideKatharine Walker
Dec 3, 2003·Journal of Pain & Palliative Care Pharmacotherapy·Joel C GlassonBrian Ginsberg
Apr 17, 2004·Anesthesiology·Alparslan TuranImran Kurt
Dec 6, 2005·Aesthetic Plastic Surgery·Alan A ParsaFereydoun Don Parsa

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Citations

Sep 18, 2013·Archives of Orthopaedic and Trauma Surgery·Mohsen Mardani-KiviKhashayar Saheb-Ekhtiari
Mar 25, 2010·Aesthetic Plastic Surgery·Fereydoun Don ParsaShannon Koehler
Feb 9, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Avi A Weinbroum
Nov 19, 2009·Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology·Carlo Luca RomanòGiuseppe Mineo
Mar 31, 2015·The Journal of Veterinary Medical Science·Giulianne Carla CrociolliGabriel Montoro Nicácio
Mar 29, 2016·Archives of Plastic Surgery·Fereydoun Don ParsaNatalie Niloufar Parsa
Dec 3, 2010·Plastic and Reconstructive Surgery·Charles H Thorne
Mar 29, 2014·Plastic and Reconstructive Surgery·David A Hidalgo, Jason A Spector
Jan 28, 2020·Plastic and Reconstructive Surgery·Fereydoun Don ParsaAlan A Parsa
Feb 19, 2020·Facial Plastic Surgery & Aesthetic Medicine·Christopher Ian NewberryEric W Cerrati
Oct 1, 2019·Plastic and Reconstructive Surgery·Rebecca C O'NeillSteven P Davison
Jul 11, 2014·JAMA Facial Plastic Surgery·Behrad B AynehchiDavid B Rosenberg
Aug 24, 2012·Aesthetic Surgery Journal·Sharon S StanleyFrank S Ciminello
Mar 24, 2017·Aesthetic Surgery Journal·Fereydoun Don ParsaAlan A Parsa
Apr 3, 2018·Aesthetic Surgery Journal·Thu-Hoai C NguyenClayton L Moliver
Dec 29, 2020·Hand : Official Journal of the American Association for Hand Surgery·Julian ZangrilliMichael Rivlin
May 6, 2021·Animals : an Open Access Journal From MDPI·Cecilia VulloGiuseppe Catone
Jul 18, 2021·Aesthetic Surgery Journal·Kelly P SchultzNorman H Rappaport
Nov 10, 2021·The Cochrane Database of Systematic Reviews·Kevin M KliftoGedge D Rosson
Dec 7, 2021·Journal of Reconstructive Microsurgery·Pope RodnoiNicholas T Haddock

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