Combined pulmonary fibrosis and emphysema (CPFE): what radiologist should know

La Radiologia medica
Federica CiccareseMaurizio Zompatori

Abstract

Combined pulmonary fibrosis and emphysema is a relatively newly defined entity, which has been deeply studied in the recent years. Despite the wide numbers of papers on this topic, there are still several open questions about pathogenesis, epidemiology, natural history and prognosis. The diagnosis could be assessed only after HRCT scan as functional tests often result in an underestimation of this syndrome. What radiologists need to know about this syndrome consists in the heterogeneity of appearances: emphysema is mainly paraseptal and fibrotic pattern could be variable, including the variant of airspace enlargement with fibrosis which needs to be differentiated from honeycombing. A special attention must be paid on complications which could worsen the prognosis, such as pulmonary hypertension and lung cancer. Further studies are needed to address if the type of fibrotic pattern as well as fibrosis CT index could be considered as prognostic factors. Thus, the role of radiologists in the management of these patients is crucial as it involves diagnosis, detection of complications and could possible concerns the identification of patients at higher risk.

References

Jan 1, 1993·Respiration; International Review of Thoracic Diseases·N HiwatariT Takishima
Oct 6, 2005·The European Respiratory Journal·V CottinUNKNOWN Groupe d'Etude et de Recherche sur les Maladies Orphelines Pulmonaires (GERM O P)
Sep 17, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Anil K AttiliFernando J Martinez
Mar 3, 2009·Respiratory Medicine·Takanori AkagiKentaro Watanabe
Aug 1, 2009·The European Respiratory Journal·V CottinUNKNOWN GERM"O"P
Jan 7, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Yoshiaki KitaguchiKeishi Kubo
Jun 16, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Kazuyoshi KurashimaYutaka Sugita
Jul 12, 2011·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·C-H LeeY-S Shim
Jan 5, 2012·Chest·Matthew D Jankowich, Sharon I S Rounds
Jan 13, 2012·Respiratory Research·Marco ChilosiAndrea Rossi
Jan 13, 2012·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Elena PeñaSusana Hernández Muñiz
Jul 12, 2012·Current Opinion in Pulmonary Medicine·Vincent Cottin, Jean-François Cordier
Feb 1, 2013·Expert Review of Respiratory Medicine·Spyros A PapirisDemosthenes Bouros
Jun 4, 2013·European Respiratory Review : an Official Journal of the European Respiratory Society·Vincent Cottin
Jul 9, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Marco ChilosiVenerino Poletti
Sep 3, 2013·European Respiratory Review : an Official Journal of the European Respiratory Society·Antonella CaminatiSergio Harari
Sep 17, 2013·American Journal of Respiratory and Critical Care Medicine·William D TravisUNKNOWN ATS/ERS Committee on Idiopathic Interstitial Pneumonias
Sep 21, 2013·Respiratory Medicine·Aline BodletCaroline Dahlqvist
Jan 28, 2014·Respiratory Medicine·Nakwon KwakChang-Hoon Lee
Dec 3, 2014·European Respiratory Review : an Official Journal of the European Respiratory Society·Maurizio ZompatoriLuca Fasano
Sep 22, 2015·The British Journal of Radiology·Yong Seek KimHye Mi Choi
Oct 6, 2015·World Journal of Radiology·Anastasia OikonomouPanos Prassopoulos

❮ Previous
Next ❯

Citations

Jul 1, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Rahul SanganiSunil Sharma
Nov 19, 2019·Respiratory Medicine·Andrea FranconeriLorenzo Cavagna

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Nicolas GirardJean-François Cordier
Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Olívia Meira DiasCarlos Roberto Ribeiro Carvalho
© 2022 Meta ULC. All rights reserved