PMID: 9526832Apr 4, 1998Paper

Combined pulmonary toxicity of diethyldithiocarbamate and lead (II) oxide in rats

Journal of Applied Toxicology : JAT
E TátraiG Ungváry

Abstract

The pulmonary toxicity of sodium diethyldithiocarbamate and lead(II) oxide alone or in combination was studied in rats after a single intratracheal instillation. The lead content in the lungs and the whole blood was determined and it has been found that the clearance of lead from the lung was delayed by dithiocarbamate complex formation, which probably had a role in increased IgA levels in the bronchoalveolar fluid and the induction of local immune response. The combined exposure gave rise to calcium deposits in the lungs both extra- and intracellularly after 1 month of exposure. Both separate and combined exposure invoked permanent injury in membranes or dystrophic changes in the cytoplasm of pneumocytes, which may initiate and generate a series of events leading to fibrosing alveolitis.

Citations

Apr 5, 2001·Journal of Applied Toxicology : JAT·E TátraiG Ungváry
Dec 18, 2001·Journal of Applied Toxicology : JAT·E TátraiG Ungváry
Aug 30, 2013·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Katarzyna KaczyńskaMałgorzata Szereda-Przestaszewska
May 25, 2011·Journal of Electron Microscopy·Katarzyna KaczynskaMałgorzata Szereda-Przestaszewska
Oct 8, 1999·Journal of Applied Toxicology : JAT·Z AdamisG Ungváry

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