Combined radiology and cytology in the diagnosis of bone lesions: a retrospective study of 370 cases

Acta Orthopaedica Scandinavica
Veli SöderlundAndris Kreicbergs

Abstract

Some of the risks with open biopsy can be avoided by fine-needle aspiration biopsy. The diagnostic contribution of radiologic findings has not been systematically studied. We retrospectively analyzed the validity of combined radiology and fine-needle aspiration cytology for the diagnosis of bone lesions in a consecutive series of 370 patients. The treatment diagnosis was based solely on radiology and cytology in 234 cases, whereas in 136 cases histopathology was also applied. Comparison of radiology and cytology showed diagnostic compliance in 256 cases (69%) and non-compliance in 101 (28%). 13 (3%) cases failed to yield diagnostic material for cytology. Among the 256 compliant cases, the diagnostic error rate was 1% (2 were falsely benign), whereas the corresponding rate was 17% among the 101 non-compliant cases. In the latter group, 36 cases yielded only normal cells at aspiration, out of which 20 proved to have a neoplastic lesion (8 metastases, 12 benign). The overall sensitivity of cytology alone in recognizing malignancy was 90%. The specificity was 95%. Given a malignant or benign diagnosis, the positive predictive value was 97% and the negative predictive value was 84%. Our study suggests that a simple approach based on...Continue Reading

References

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May 16, 2000·Clinical Orthopaedics and Related Research·W G Ward, S Kilpatrick
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Citations

Oct 2, 2009·Diagnostic Cytopathology·Lester J LayfieldSusie Newman Crabtree
Sep 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Sudipta ChakrabartiMichael Hira
Apr 28, 2005·The Journal of Bone and Joint Surgery. British Volume·H C F Bauer
Jan 27, 2006·Japanese Journal of Clinical Oncology·Alpay OrkiBulent Arman
Mar 22, 2016·Cancer Cytopathology·Christopher J VandenBusscheSyed Z Ali

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