Combined scopolamine and ethanol treatment results in a locomotor stimulant response suggestive of synergism that is not blocked by dopamine receptor antagonists.

Alcoholism, Clinical and Experimental Research
Angela C Scibelli, Tamara J Phillips

Abstract

Muscarinic acetylcholine receptors (mAChRs) are well positioned to mediate ethanol's stimulant effects. To investigate this possibility, we examined the effects of scopolamine, a receptor subtype nonselective mAChR antagonist, on ethanol-induced stimulation in genotypes highly sensitive to this effect of ethanol. We also investigated whether the dopamine D1-like receptor antagonist, SCH-23390 or the dopamine D2-like receptor antagonist, haloperidol, could block the extreme stimulant response found following co-administration of scopolamine and ethanol. Scopolamine (0, 0.0625, 0.125, 0.25, or 0.5 mg/kg) was given 10 minutes prior to saline or ethanol (0.75 to 2 g/kg) to female FAST (Experiment I) or DBA/2J (Experiment II) mice that were then tested for locomotion for 30 minutes. In Experiments III and IV, respectively, SCH-23390 (0, 0.015, or 0.03 mg/kg) was given 10 minutes prior, and haloperidol (0, 0.08, or 0.16 mg/kg) was given 2 minutes prior, to scopolamine (0 or 0.5 mg/kg), followed 10 minutes later by saline or ethanol (1.5 g/kg) and female DBA/2J mice were tested for locomotion for 30 minutes. FAST and DBA/2J mice displayed a robust enhancement of the locomotor effects of ethanol following pretreatment with scopolamine ...Continue Reading

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Citations

Jan 10, 2014·Invertebrate Neuroscience : in·Latha RamakrishnanMichael R Eggerichs
Jan 28, 2015·Alcoholism, Clinical and Experimental Research·Noah R GubnerTamara J Phillips
Dec 28, 2010·Pharmacology, Biochemistry, and Behavior·Rosana CamariniHelena Maria Calil
Mar 11, 2011·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Ping ChenD G Georgiev

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