Combined Small Cell Carcinoma of the Lung: Is It a Single Entity?

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Xiaoliang ZhaoGiuseppe Giaccone

Abstract

SCLC accounts for 15% and 20% of all lung cancers, with combined SCLC (CSCLC) comprising 2% to 5%. Little is known about the clinical characteristics and molecular changes associated with the various histologic components. A total of 205 SCLC cases were resected between 2005 and 2015. Clinical and pathologic features were analyzed. All CSCLC cases were confirmed by histologic examination and immunohistochemistry. The individual components were microdissected using a novel automated dissection system, and DNA was extracted and subjected to targeted exome sequencing. A total of 10 cases of CSCLC were identified out of 170 cases with adequate histologic material; squamous cell carcinoma comprised the second component in half of these (n = 5). There were no significant differences between CSCLC and pure SCLC with respect to clinical features. The median follow-up time was 36 months. The median survival times of patients with pure SCLC and CSCLC were 58 months and 26 months, respectively (p = 0.030). The different components of three cases of CSCLC were deemed adequate for microdissection and sequencing. Approximately 75% of the identified somatic mutations were present in both components. There were also 15 gene mutations or six am...Continue Reading

Citations

May 10, 2019·The Oncologist·Megumi FurutaUNKNOWN Hokkaido Lung Cancer Clinical Study Group
Dec 16, 2020·Molecular Oncology·Xiaoliang ZhaoGiuseppe Giaccone
Feb 13, 2021·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K D LachP O Fiset
Jan 27, 2019·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kousuke WatanabeTakahide Nagase
Jun 6, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiaoji ChenMinetta C Liu
Aug 28, 2021·Cancers·Shi-Ming TuLouis L Pisters
Feb 9, 2019·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Xiaoliang ZhaoGiuseppe Giaccone
Oct 22, 2021·International Journal of Cancer. Journal International Du Cancer·Bregtje C M HermansUNKNOWN PALGA-group

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