Abstract
The purpose of this study is to determine prognostic factors and survival in patients who present with combined small-cell lung cancer (SCLC). A retrospective review of combined SCLC histology in patients treated between1995-2010 was undertaken. Demographics, diagnostic information, disease characteristics, treatment modality, and survival were captured. Survival estimates were performed using Kaplan Meier analysis. Statistical significance was defined as P < 0.05. Forty-one patients were identified, and 35 records were available for analysis. Median age at diagnosis was 68 (range 50-85). The study included 20 (57%) women and 15 (43%) men; and 94% had a current or former history of smoking. Histology was SCLC/large cell carcinoma not otherwise specified in 28 (80%), and SCLC/adenocarcinoma or SCLC/squamous cell carcinoma in seven (20%). Cardiac or pulmonary comorbidities were present in 80% of patients, and 24 patients had metastatic disease at presentation. Twenty-eight patients received treatment of chemotherapy (n = 24), cranial radiotherapy (n = 5), or thoracic radiotherapy (n = 7). Staging was as follows: stage I-III (n = 11), stage IV (n = 24). Median survival was 15.4 months (range <1-53 months) and 3.4 months (range <1-...Continue Reading
References
May 1, 1986·Chest·D J AdelsteinJ D Hines
Mar 1, 1969·Cancer·Y KatoT H Burford
Dec 15, 1982·Cancer·P A RadiceJ D Minna
Apr 1, 1994·American Journal of Clinical Pathology·V L Roggli
Jun 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A CoatesD Osoba
Sep 10, 2002·The American Journal of Surgical Pathology·Siobhan A NicholsonWilliam D Travis
Mar 1, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Roy M BremnesUNKNOWN Norweigian Lung Cancer Study Group
Jul 22, 2004·Journal of the National Cancer Institute·R W FieldC F Lynch
May 19, 2005·Seminars in Roentgenology·Mary Beth BeasleyWilliam D Travis
Sep 30, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ramaswamy GovindanJay Piccirillo
Oct 5, 2007·The Oncologist·Brian E LallyMichael C Perry
Feb 21, 2009·American Journal of Clinical Pathology·Patrick L WagnerAnjali Saqi
May 10, 2011·Clinical Lung Cancer·Shadi Haddadin, Michael C Perry
May 14, 2011·Lancet·Jan P van MeerbeeckDirk K M De Ruysscher
May 31, 2011·The European Respiratory Journal·M PaesmansJ P Sculier
Oct 18, 2011·Clinical Lung Cancer·Laurie E GasparJames A Bonner
Nov 26, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Joseph TreatMark A Socinski
Jan 11, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·William D Travis
Citations
May 14, 2016·Endocrine Pathology·Stefano La RosaSilvia Uccella
Nov 1, 2017·Biomedical Reports·Betul Celik, Tangul Bulut
Mar 30, 2019·Annals of Surgical Oncology·Misaki IijimaHiroyuki Kuwano
Aug 28, 2018·Internal Medicine·Shinichi MoritaShuji Terai