PMID: 2107150Mar 1, 1990Paper

Combined sotalol and flecainide given at low dosage in patients with the Wolff-Parkinson-White syndrome

International Journal of Cardiology
H D GössingerH Mösslacher

Abstract

We determined the effects of combined sotalol (160 mg/day) and flecainide (200 mg/day) in 15 patients with the Wolff-Parkinson-White syndrome. After medication given for 3 days, the plasma levels were 0.8 +/- 0.3 micrograms/ml for sotalol and 232 +/- 104 ng/ml for flecainide. Electrophysiologic testing showed complete blockade of the accessory pathway in 4 patients and a decrease in the anterograde conduction capacity by 27% in the remainder. The effect on the accessory pathway was unrelated to the resting conduction properties. Initiation of circus movement tachycardia was prevented in 5 of 11 patients. During a median period of 28 months of follow-up, 87% of patients were either free of tachycardia or satisfactorily improved. No proarrhythmic or adverse drug effects were observed.

Citations

Aug 19, 2006·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Girish NarayanJasbir Sra
Feb 2, 2002·Journal of the American College of Cardiology·Jack F PriceArnold L Fenrich
Feb 24, 2006·Archives of Disease in Childhood. Fetal and Neonatal Edition·D S Kothari, J R Skinner
Aug 20, 1992·The American Journal of Cardiology·I Crozier
Jun 15, 2005·Expert Opinion on Pharmacotherapy·D P RedfearnG J Klein
Nov 1, 1993·The Annals of Pharmacotherapy·J M Nappi, P L McCollam

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