Combined squamous cell carcinoma and malignant melanoma of the eyelid

Klinische Monatsblätter für Augenheilkunde
J Hua, C Auw-Hädrich

Abstract

We present a case report of co-existent components of squamous cell carcinoma and malignant melanoma within a solid eyelid tumour in a 74-year-old male. The particular composite of these two malignancies in ocular adnexa is to the best of our knowledge reported for the first time. The histological findings exhibited a solid anterior lid tumour infiltrating the skin and surrounding conjunctiva, as well as the orbicular muscles. The hyper- and parakeratotic keratin-rich squamous cell carcinoma was cytokeratin AE1/AE3 positive, had a slight atypia but an obvious invasion in the depth. Between the squamous cell carcinoma cells were islands of HMB45 and Melan-A positive melanoma cells with slight pigmentation, which demonstrated not only subcutaneous but also intraepithelial invasion.

Citations

Jul 7, 2012·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·P Dierks, W Wiegand

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