Combined St. Thomas and histidine-tryptophan-ketoglutarat solutions for myocardial preservation in heart transplantation patients

Transplantation Proceedings
K C LeeJ Wei

Abstract

To establish quicker cardiac arrest and less myocardial distension injury during heart procurement, we combined St. Thomas and histidine-tryptophan-ketoglutarate (HTK) solutions for donor heart preservation since June 2008. From June 2008 to March 2010, we enrolled 31 heart transplantation (HT) patients in this study. During heart procurement we initially infused 1,000 mL cold St Thomas cardioplegic solution to achieve cardiac arrest. After procurement, a further 2,000 mL of cold HTK solution was infused at low perfusion pressure. Another 1,000 mL cold HTK solution was perfused before donor heart implantation. We examined donor age, recipient preoperative characteristics, ischemia time, hospital stay, postoperative graft function, major cardiac events, and transplant vasculopathy (TCAD). Twenty-two patients (71.0%) presented with dilated cardiomyopathy and 7 (23.3%) with ischemia cardiomyopathy. There were 23 (76.7%) male donors, and the mean donor age was 38.4 ± 13.8 years. Six patients underwent a redo sternotomy, 1 patient needed a third-do sternotomy, and 1 a seventh sternotomy (third HT) for repeated endocarditis and graft failure. The average ischemia time was 224.9 ± 71.0 minutes and the postoperative hospital stay was 5...Continue Reading

References

Oct 1, 1980·The Thoracic and Cardiovascular Surgeon·H J Bretschneider
Sep 1, 1993·Cardiovascular Research·D Garcia-Dorado, J Oliveras
Aug 24, 1999·Transplantation Proceedings·F MühlbacherC Mittermayer
Aug 24, 1999·Transplantation Proceedings·M GarlickiA Dziatkowiak
Oct 11, 2005·Transplantation Proceedings·A ArslanS Aslamaci
May 24, 2007·Transplantation·Mark-Hugo J MaathuisRutger J Ploeg

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Citations

Dec 30, 2014·Interactive Cardiovascular and Thoracic Surgery·Sarkis M MinasianTimur D Vlasov
Jan 17, 2015·Frontiers in Surgery·Hendrik T Tevaearai StahelThierry P Carrel
Oct 14, 2020·The Korean Journal of Thoracic and Cardiovascular Surgery·Hong Rae KimJae Won Lee

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