Combined therapy with GnRH analogue and growth hormone increases adult height in children with short stature and normal pubertal onset.

Endocrine
Shuying LiXueyan Wu

Abstract

To investigate whether gonadotropin releasing hormone analogue (GnRHa) combined with recombinant human growth hormone (rhGH) can improve the adult height (AHt) of children with short stature and normal pubertal onset. In this retrospective study, GnRHa/rhGH treatment was given to children with normal pubertal onset and short stature. Patients were followed up to measure their AHt. The primary outcomes were the disparity between AHt standard deviation score (AHt SDS) and pre-treatment height standard deviation score (Ht SDS) and the disparity between AHt and target height (THt). A total of 94 patients were included. Forty-nine boys were treated with GnRHa/rhGH for 24.84 ± 13.01 months, and 45 girls were treated for 23.89 ± 10.43 months. (2) Before treatment, the Ht SDS of boys and girls was -1.82 ± 1.30 and -1.10 ± 1.61, respectively, and the target height was 168.98 ± 3.51 cm and 157.90 ± 3.25 cm, respectively. (3) After treatment, for boys, the AHt SDS increased by 1.37 ± 1.28 (p = 0.000) and the disparity between AHt and THt was 0.98 ± 6.18 cm (p = 0.273); for girls, the AHtSDS increased by 1.28 ± 1.48 (p = 0.000), and the disparity between AHt and THt was 3.64 ± 4.86 cm (n = 45, p = 0.000). (4) Subgroup analysis showed that,...Continue Reading

References

Jul 1, 1994·The Journal of Pediatrics·R LindsayM Rallison
Feb 26, 2000·The Journal of Clinical Endocrinology and Metabolism·A M PasquinoM Segni
Jan 15, 2002·The Journal of Clinical Endocrinology and Metabolism·Verónica MericqFernando Cassorla
Jan 15, 2002·The Journal of Clinical Endocrinology and Metabolism·Pinchas CohenUNKNOWN American Norditropin Clinical Trials Group
Mar 7, 2003·The New England Journal of Medicine·Jack A YanovskiGordon B Cutler
Sep 2, 2004·European Journal of Endocrinology·J M WitW Oostdijk
Mar 27, 2007·Acta Paediatrica·Hanneke Visser-van BalenGerben Sinnema
Jan 10, 2008·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·J M WitP Cohen
Mar 1, 2009·Journal of Clinical Research in Pediatric Endocrinology·Stefania PedicelliStefano Cianfarani
Mar 15, 2011·BMJ : British Medical Journal·Annalisa Deodati, Stefano Cianfarani
Apr 18, 2012·Hormone Research in Pædiatrics·Lars SävendahlJudith Ross
May 6, 2014·JAMA : the Journal of the American Medical Association·Laurie E Cohen
Sep 14, 2015·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Judith L RossJohn Germak
Jan 19, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Lucia SchenaMauro Bozzola
Mar 10, 2017·Seminars in Reproductive Medicine·Matthew Joseph Biehl, Lori Therese Raetzman
Oct 13, 2017·Annals of Pediatric Endocrinology & Metabolism·Min Jae Kang
Oct 22, 2018·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Yan-Qin YingXiao-Ping Luo
Nov 2, 2018·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Marie Christianne Sandhya Ravi ChandarPriya Vaidyanathan
Mar 27, 2019·The Journal of Clinical Endocrinology and Metabolism·Liora LazarYael Lebenthal
Apr 18, 2019·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Nahla KhawajaKamel M Ajlouni
Oct 17, 2019·Frontiers in Endocrinology·João Soares FelícioJoão Felício Abrahão Neto
Oct 23, 2019·Journal of the Endocrine Society·Adda Grimberg, Genevieve P Kanter
Nov 14, 2019·Expert Review of Endocrinology & Metabolism·Kevin C J YuenBradley S Miller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved