Combined Therapy with Shock Wave and Retrograde Bone Marrow-Derived Cell Transplantation for Osteochondral Lesions of the Talus

Scientific Reports
Fuqiang GaoWanshou Guo

Abstract

Multiple treatment strategies have been developed for osteochondral lesions (OCLs) of the talus. The purpose of this retrospective study was to assess retrograde autologous bone marrow cell (BMC) transplantation via core drilling (CD) combined with focused extracorporeal shock wave treatment (ESWT) in undisplaced OCL of the talus. A total of 69 patients with unilateral osteochondral lesions of the talus (Hepple grade I-III) were divided into two groups: 41 patients received combined therapy of ESWT and BMC transplantation (group A), while 28 were administered BMC transplantation alone (group B). The patients were followed up clinically and radiographically for a minimum of 2 years. Mean follow-up was 4.1 ± 2.8 years. AOFAS scores increased more significantly while pain intensity levels decreased in group A after treatment, compared with group B values (P < 0.001). In MRI follow-up, a more remarkable improvement of OCLs of the talus was observed in group A compared with group B (P = 0.040). Therefore, the combined technique reported here is a highly effective therapeutic option in OCLs of the talus with intact cartilage. It promotes patient recovery with pain control, and improves clinical outcome for more than 2 years after sur...Continue Reading

References

Jul 1, 1994·Foot & Ankle International·H B KitaokaM Sanders
Dec 28, 1999·Foot & Ankle International·S HeppleD Glew
Oct 18, 2001·Clinical Orthopaedics and Related Research·J R SteadmanJ J Rodrigo
May 11, 2002·The Journal of Bone and Joint Surgery. British Volume·L SchumanC N van Dijk
Oct 14, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ching-Jen WangLin-Cheng Yang
Apr 26, 2006·The American Journal of Sports Medicine·Michihaya KonoMitsuo Ochi
Jan 10, 2008·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Bavornrit ChuckpaiwongGeorge H Theodore
Jan 30, 2009·Foot & Ankle International·Padhraig F O'LoughlinJohn G Kennedy
May 19, 2009·Clinical Orthopaedics and Related Research·Sandro GianniniBrunella Grigolo
Jul 2, 2009·Radiology·Christian J SeebauerUlf K M Teichgräber
Aug 6, 2009·The American Journal of Sports Medicine·Woo Jin ChoiJin Woo Lee
Oct 28, 2009·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Maartje ZengerinkCornelis Niek van Dijk
Aug 20, 2010·The Journal of Bone and Joint Surgery. American Volume·Lisa A FortierAlan J Nixon
Oct 23, 2010·Foot & Ankle International·Florian GrasGunther O Hofmann
Jun 7, 2012·Clinical Orthopaedics and Related Research·Roger LyonJoseph Schwab
Mar 22, 2013·The Journal of Bone and Joint Surgery. American Volume·Christiaan J A van BergenC Niek van Dijk
Jul 23, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Byoung-Hyun MinJeong Ho Yoon
Nov 13, 2013·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Pietro RomeoValerio Sansone
Feb 5, 2014·The Bone & Joint Journal·C P HannonJ G Kennedy
Jul 13, 2014·Foot & Ankle International·Thomas O ClantonLauren M Matheny
Aug 8, 2014·Foot & Ankle Specialist·Ian Savage-ElliottJohn G Kennedy
Jan 21, 2015·Orthopaedics & Traumatology, Surgery & Research : OTSR·N de l'EscalopierG Versier
Feb 5, 2015·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Jun-Ik Choi, Keun-Bae Lee
Apr 23, 2015·Orthopedics·Fuqiang GaoKoji Ozaki
May 13, 2015·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Ethan J FraserJohn G Kennedy

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Olivier Barbier
Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA
Alberto VenturaEnrico Borgo
Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA
Xi-Liang ShangYing-Hui Hua
© 2022 Meta ULC. All rights reserved