Combined therapy with thioridazine decreases plasma levels of quetiapine inTaiwanese schizophrenic patients

Therapeutic Drug Monitoring
Shen-Chieh ChangTzu-Hua Wu

Abstract

In this study, the authors studied the effect of thioridazine (TDZ) on the pharmacokinetic profile of quetiapine (QTP) in Taiwanese patients with schizophrenia. Sixteen subjects with schizophrenia were recruited for this study. The authors pretreated 8 patients with TDZ 50 mg daily continuously given until the end of the study. QTP was administered to all the participants, and their doses were escalated to 300 mg once daily over a 7-day period and maintained for another week. On day 15, blood samples were collected at 12 time points within an 8-hour interval. The authors assayed the plasma levels of QTP with a high-performance liquid chromatography system coupled with ultraviolet detector. Significantly decreased plasma levels of QTP after oral administration were observed in patients comedicated with TDZ compared with the QTP monotherapy group at 1.5, 2, and 2.5 hours, and the P values were 0.046, 0.001, and 0.005, respectively. The Cmax of QTP was significantly lower in the group comedicated with TDZ (776.9 ± 175.2 versus 1452.3 ± 707.5 ng/mL; P = 0.002). The oral clearance of QTP was significantly higher in the combined group than in the monothreapy group (123.3 ± 66.8 versus 60.3 ± 28.5 L/h; P = 0.03). Other pharmacokinetic...Continue Reading

References

Sep 19, 2000·British Journal of Pharmacology·W A DanielJ Wójcikowski
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May 2, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Hongwu ShenChuan Li
Oct 27, 2007·The Journal of Clinical Psychiatry·Ingrid CastbergOlav Spigset

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