Combined toxicity of ethanol and methylmercury in rat

Toxicology
S I McNeilC J Turner

Abstract

The hepatotoxic and nephrotoxic effects of methylmercury (CH3Hg) and ethanol (EtOH) are well known; however, their interaction in vivo is not clearly understood. In order to investigate the combined effects of these 2 substances, 4 groups of male Wistar rats with an initial weight of approximately 190 g were treated for 7 weeks. Each group consisting of 8 rats was gavaged as follows: Group 1 with 5.0 ml/kg body weight of double distilled water, Group 2 with 5.0 ml/kg body weight of 25% EtOH, Group 3 with 2.5 mg/kg of CH3Hg in water, and Group 4 with 2.5 mg/kg of CH3Hg in 25% EtOH. At the termination of the experiment the mean body weights of the rats in Group 3 (372.5 +/- 10.8 S.E.) and Group 4 (383.4 +/- 13.4) were significantly lower than that of Group 1 (433.0 +/- 7.8). Linear regression showed a positive feed conversion efficiency for Groups 1 and 2 (1.07 and 0.83, respectively), and a negative score for this parameter for Groups 3 and 4 (-1.43, -1.53). At necropsy, rat livers from Group 3 exhibited random multifocal tan spots. The relative liver weights were similar to those of controls. Semithin sections of liver revealed an increase in lipid droplets in Groups 2 and 3 compared to those in the other 2 groups while vacuoli...Continue Reading

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Citations

Jan 1, 1990·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H Zaporowska, W Wasilewski
Jun 29, 2010·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Christy C Bridges, Rudolfs K Zalups
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Dec 14, 2018·Environmental Science and Pollution Research International·Shaukat AliMazhar Ulhaq

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