Abstract
The prognosis for patients with advanced (stage III and IV) hepatocellular carcinoma (HCC) remains poor. Liver resection and liver transplantation have limited effects on overall survival. Our study was carried out to assess a novel therapeutic approach, which includes transarterial locoregional chemotherapy and in vivo locoregional dual immunostimulation, in patients with unresectable HCC. A group of 20 patients with stage III and IV hepatocellular carcinoma had 10 courses (once per day) of transarterial targeted locoregional immunotherapy with interferon-gamma (IFN-gamma) and interleukin-2 (IL-2), emulsified in a Lipiodol-Urografin mixture. The target organs were the spleen and the liver tumor itself. One course of intrahepatic locoregional targeting transarterial chemotherapy was given 10 days after completion of immunotherapy (mitomycin C, carboplatin, Farmorubicin, Leucovorin, 5-fluorouracil, and IFN-gamma). This was followed after 2 months by another course of transarterial targeted locoregional immunotherapy-chemotherapy. All patients survived the operation and had a mean survival time of 18 months (4-22 months). There was a decrease in the tumor size of 14 of the 20 patients. Serum alpha-fetoprotein (AFP) levels decline...Continue Reading
References
Feb 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G M MavligitS Wallace
Mar 1, 1989·Radiology·H NakamuraS Sawada
Jan 1, 1989·Cancer·S TakagiT L Whiteside
Feb 1, 1988·Gastroenterology·D Y LinC M Lai
Dec 22, 1988·The New England Journal of Medicine·S A RosenbergC A Seipp
Oct 1, 1984·Cancer·N NagasueK Inokuchi
Citations
Dec 1, 2005·Anti-cancer Drugs·Carlos GrandeJoaquin Casal
Mar 11, 2009·Journal of Biomedical Science·Pablo MatarGuillermo Mazzolini
Apr 15, 2008·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Hong-yun Chen, Zhe Chen
Sep 10, 2014·Expert Review of Anticancer Therapy·Sameh MikhailAmer Zeidan
Jun 22, 2011·Clinics in Liver Disease·Stephen H WrzesinskiMario Strazzabosco
Mar 23, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Yanhui XuDavid E Kaplan
Aug 30, 2008·Surgical Oncology Clinics of North America·Akira Yamamoto, Takami Sato
Jun 12, 2013·International Journal of Cancer. Journal International Du Cancer·I-Cheng LeeHan-Chieh Lin
Oct 19, 2006·Journal of Hepatology·Tim F GretenFirouzeh Korangy
Feb 8, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A ZerbiniG Missale
Feb 6, 2014·Oncoimmunology·Jana C Mossanen, Frank Tacke
Sep 23, 2014·Anti-cancer Drugs·Shoupeng ShengZhiling Qian
Apr 25, 2006·Clinical Imaging·Herwig CerwenkaJohann Raith
Sep 24, 2016·American Journal of Surgery·Masha ZeltsmanPrasad S Adusumilli
Oct 31, 2012·Digestive Diseases·Nathalie SchmidtRobert Thimme
May 9, 2015·World Journal of Hepatology·Yu-Peng HongQi Zhang
Apr 24, 2019·Radiology·Joseph P ErinjeriS Nahum Goldberg
Sep 1, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yasuhiko YoshidaJiro Fujimoto
Jul 14, 1998·American Journal of Hematology·R V Gardner
Apr 21, 2010·Cancer Control : Journal of the Moffitt Cancer Center·Jennifer L GigliaSteven E Finkelstein