Combined treatment strategies in gastrointestinal stromal tumors (GISTs) after imatinib and sunitinib therapy

Cancer Treatment Reviews
Maria A PantaleoGuido Biasco

Abstract

Resistance to tyrosine-kinase inhibitors remains an open issue in the treatment of patients with gastrointestinal stromal tumors. The complex biology of disease in the multi-resistant setting has led a progressively growing urgency and interest in development combined or integrated therapies. This mini-review outlines the rationale for developing new combined therapeutic approaches, and describes the state of the art of the various potential strategies and the promising research perspectives.

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Citations

Nov 17, 2010·Journal of Translational Medicine·Maria A PantaleoGuido Biasco
Jan 5, 2011·Journal of Experimental & Clinical Cancer Research : CR·Maria Abbondanza PantaleoGuido Biasco
Mar 10, 2011·Expert Opinion on Therapeutic Targets·Margherita NanniniMaria A Pantaleo

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