Combined treatment with artificial dermis and basic fibroblast growth factor for cranial bone-exposing wounds

Journal of Tissue Viability
Hiroto SaijoMasaki Fujioka

Abstract

Cranial bone-exposing wounds should be resurfaced as soon as possible using flaps. However, early one-stage wound closure is sometimes difficult due to the poor general condition of the patient or equipment shortages. Artificial dermis composed of atelocollagen sponge is useful for reconstructing bone-exposing wounds. In addition, the treatment of wounds with basic fibroblast growth factor helps more severe wounds to heal faster. We employed combined treatment with artificial dermis and basic fibroblast growth factor to treat cranial bone-exposing wounds in 2 cases, and we describe these cases here. Case 1: A 56-year-old man suffered severe burns, which exposed the occipital bone and mandible, after attempting suicide. Case 2: A 79-year-old woman suffered a full-thickness skin defect on her forehead due to a fall, which resulted in her frontal bone being exposed. Both patients underwent combined treatment with artificial dermis and basic fibroblast growth factor, followed by free skin grafting. The combined treatment promoted the formation of granulation tissue, which acted as a wound bed for the subsequent skin grafting. The free skin grafting resulted in the complete resurfacing of the patients' wounds. Combined treatment wit...Continue Reading

References

Jul 1, 1997·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·M Fujioka, T Fujii
Sep 24, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Akihiro KanematsuYasuhiko Tabata
May 18, 2005·Burns : Journal of the International Society for Burn Injuries·Gan MuneuchiHiroharu H Igawa
Oct 4, 2005·Burns : Journal of the International Society for Burn Injuries·Sadanori AkitaAkiyoshi Hirano
Jan 9, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Sadanori AkitaAkiyoshi Hirano
Jun 25, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Masaki Fujioka
Dec 22, 2009·Expert Review of Medical Devices·Simone C RizziTim R Dargaville
Aug 1, 2010·Seminars in Plastic Surgery·Andrew Burd

❮ Previous
Next ❯

Citations

Aug 29, 2019·Frontiers in Endocrinology·Marina Di DomenicoMariarosaria Boccellino
Jun 4, 2020·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Sharon Claudia NotodihardjoKenji Kusumoto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.