PMID: 9176084Apr 1, 1997Paper

Combined treatment with C1 esterase inhibitor and antithrombin III improves survival in severe acute experimental pancreatitis

Gut
H YamaguchiG Adler

Abstract

Patients with severe acute pancreatitis die of complications closely related to the systemic activation of protease cascades. To examine the effects of human C1 esterase inhibitor (C1 INH) and antithrombin III (AT III) on two experimental models of acute pancreatitis. Oedematous pancreatitis was induced by continuous intravenous infusion of caerulein and haemorrhagic pancreatitis by retrograde injection of sodium taurocholate into the biliopancreatic duct. C1 INH and AT III were given intravenously, either before or after the induction of pancreatitis. Treatment with C1 INH and AT III had no beneficial effect on oedematous pancreatitis. On the other hand, combined C1 INH and AT III therapy improved the survival in haemorrhagic pancreatitis compared with treatment with human serum albumin. This reduction in mortality was found regardless of whether the treatment was given prophylactically or therapeutically. Treatment with C1 INH and AT III represents a promising therapeutic concept for patients with severe haemorrhagic pancreatitis.

Citations

Nov 4, 2005·Springer Seminars in Immunopathology·Marco CicardiBenedetta Cicardi
May 10, 2006·Digestive Diseases and Sciences·Laura Iris Cosen-BinkerOsvaldo Tiscornia
May 20, 2015·Expert Review of Gastroenterology & Hepatology·Vikesh K SinghEnrique de-Madaria
Apr 20, 2005·The British Journal of Surgery·T HackertJ Werner
Oct 5, 2001·Expert Opinion on Pharmacotherapy·M Kirschfink, T E Mollnes
Apr 17, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Thilo HackertJens Werner
Feb 2, 2017·Frontiers in Immunology·Lucas BettacMarkus Huber-Lang
Jun 16, 2004·Biological Chemistry·Shila M NobarJoseph G Bieth
Oct 13, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Werner HartwigJens Werner
May 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dawid MaduziaZygmunt Warzecha

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