PMID: 9548343Apr 21, 1998Paper

Combined treatment with chemotherapy and radiation therapy for intracranial germ cell tumors

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
M MatsutaniO Nakamura

Abstract

We analyzed our treatment results in 153 patients with histologically verified intracranial germ cell tumors and proposed classifying them into three therapeutic groups with good prognosis, intermediate prognosis, and poor prognosis. In this work, we selected patients treated with chemotherapy (cisplatin or carboplatin combinations) in each subgroup, and we discuss the role of chemotherapy in their treatment. Our combination chemotherapy regimens are: cisplatin-vinblastine-bleomycin, cisplatin-etoposide, and carboplatin-etoposide. We delivered these chemotherapies to the last 33 patients and compared their treatment results with those obtained in the previous 31 patients, who were treated with conventional radiation therapy alone. A combination with chemotherapy and a reduced dose of irradiation with local field was given to 7 patients with germinoma to increase the cure rate and reduce radiation-induced side effects, including anterior pituitary dysfunction. We obtained an excellent initial response to chemotherapy. The chemotherapy we delivered had significantly better effects in the group with intermediate prognosis, but not in the group with poor prognosis. More aggressive chemotherapy and radiation therapy should be given ...Continue Reading

Citations

Mar 6, 2007·Pediatric Neurosurgery·Hideo NakamuraJun-ichi Kuratsu
Nov 4, 2008·Journal of Neurosurgery. Pediatrics·Rémy NoudelPascal Rousseaux
Jun 3, 2011·Journal of Neurosurgery. Pediatrics·Yoshihiko MaedaMichiyasu Suzuki
Apr 5, 2011·Journal of Neurosurgery. Pediatrics·Hideo NakamuraJun-ichi Kuratsu
Jan 1, 2009·Pituitary·Luiz Eduardo Armondi WildembergMônica Roberto Gadelha
Oct 22, 2008·Expert Review of Neurotherapeutics·Mersiha HadziahmetovicSimon S Lo
Jul 2, 2011·The Keio Journal of Medicine·Satoshi TakahashiTakeshi Kawase
May 3, 2011·Journal of Neuro-oncology·Hideo NakamuraJun-ichi Kuratsu
Nov 1, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Aanchal KakkarChitra Sarkar
Feb 16, 2019·Pediatric Blood & Cancer·Mohammad H Abu ArjaMohamed S AbdelBaki
Feb 7, 2009·Arquivos brasileiros de endocrinologia e metabologia·Claudia Veiga ChangAna Valeria Barros de Castro
Feb 26, 2013·Medical Oncology·Jigisha P ThakkarJ Lee Villano
Jun 27, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Hu XingWu Jing-Zhan
Apr 9, 2002·Neurologia Medico-chirurgica·Kazunori FujiwaraYoshiharu Sakurai

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