Combined treatment with low dose prednisone and escin improves the anti-arthritic effect in experimental arthritis

International Immunopharmacology
Yuan DuFenghua Fu

Abstract

The present study was aimed at investigating whether low dose oral prednisone combined with escin could inhibit the progression of adjuvant-induced arthritis (AIA) in rats. Adjuvant arthritis was induced in SD rats began day 1 for 28 days. Prednisone at doses of 2, 10 mg/kg/day alone or escin at doses of 5, 10 mg/kg/day alone, or prednisone at dose of 2 mg/kg/day with escin at doses of 5 or 10 mg/kg/day were given to different groups of rats intragastrically from day 13 to 28 respectively. Paw swelling, arthritic index, histological and radiographic changes were assessed to evaluate the anti-arthritic effect. Weight growth, spleen and thymus indexes were also calculated. Serum samples were collected for estimation of pro-inflammatory cytokines. Rats developed erosive arthritis of the hind paw when immunized with adjuvant. Prednisone 2 mg/kg combined with escin 5 or 10 mg/kg significantly inhibited the paw swelling. Histopathological and radiographic analysis showed a marked decrease of synovial inflammatory infiltration, synovial hyperplasia and bone erosion by combination therapy, which also markedly suppressed the expression of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6). No significant ch...Continue Reading

References

Oct 12, 2000·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M MatsuuraT Okumoto
Jun 1, 2002·Ageing Research Reviews·Rikard HolmdahlHisakata Yamada
Aug 2, 2005·Nature Reviews. Immunology·Reina E Mebius, Georg Kraal
Jun 26, 2008·Journal of Ethnopharmacology·Hong LiDuan Li
Aug 30, 2008·Expert Opinion on Drug Delivery·Ingo H Tarner, Ulf Müller-Ladner
Oct 30, 2008·Journal of Immunotoxicology·Ping CaiRolf Konig
Mar 31, 2009·Autoimmunity Reviews·Ladislav SenoltSteffen Gay
Jun 2, 2009·Lancet·Peter J Barnes, Ian M Adcock
Oct 10, 2009·Pharmacological Reports : PR·Tian WangXiumei Zhang
Sep 21, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Wenyu XinFenghua Fu
Dec 24, 2010·Human & Experimental Toxicology·Yuan DuFeng-Hua Fu
Apr 1, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Cheng-Jian ZhengLu-Ping Qin

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Citations

Jan 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ramsia GeislerThomas Hellweg
Oct 6, 2018·European Journal of Pharmacology·Chen-Li ChengSheau-Yun Yuan
May 21, 2021·Journal of Traditional and Complementary Medicine·Vipin DhoteAditya Ganeshpurkar
Dec 7, 2021·Frontiers in Endocrinology·Leiming ZhangFenghua Fu

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