PMID: 15224711Jul 1, 2004Paper

Combined treatment with vigabatrin and topiramate in West syndrome

Journal of Child Neurology
Sabrina BuoniAlberto Fois

Abstract

The clinical and electroencephalographic (EEG) response to combined therapy with vigabatrin and topiramate was evaluated in five patients ages 7 to 15 months affected by West syndrome in an open-label trial. Four patients had cryptogenic and one patient had symptomatic (tuberous sclerosis) West syndrome. In cryptogenic patients who failed to respond to pyridoxine, vigabatrin was titrated to 80 to 100 mg/kg. Because control of infantile spasms or an EEG improvement was not obtained with vigabatrin treatment, topiramate was added (3-3.8 mg/kg/day). In all patients, the combined therapy with topiramate and vigabatrin achieved a rapid and complete normalization of infantile spasms, and in three patients with cryptogenic West syndrome, the EEG also became normal. In only one patient, transient anorexia was observed. This drug combination led to rapid neurodevelopmental normalization in cryptogenic patients. The results are promising and justify more trials in larger numbers of children with West syndrome.

Citations

Jan 5, 2007·Indian Journal of Pediatrics·R Fallah
Nov 11, 2006·Clinical Neuropharmacology·Li-Ping ZouEilhard Mix
Feb 20, 2009·Journal of Child Neurology·Bradley PeltzerBrenda E Porter
Feb 26, 2010·Italian Journal of Pediatrics·Alberto Fois
Jun 27, 2009·Neuropsychiatric Disease and Treatment·Chang-Yong Tsao
Aug 30, 2008·Paediatric Drugs·Darcy A Krueger, David N Franz
Jun 8, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Mehmet CanpolatSefer Kumandas
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