Combined Use of Common Fecal and Blood Markers for Detection of Endoscopically Active Inflammatory Bowel Disease.

Clinical and Translational Gastroenterology
Lung-Yi MakWai K Leung

Abstract

Monitoring of disease activity is essential in patients with inflammatory bowel disease. Although endoscopic remission is the ideal therapeutic goal, noninvasive biomarkers (blood and fecal) are more acceptable to patients and are less costly. We evaluated the performance of combinations of fecal and blood markers on the detection of endoscopically active disease. Patients with ulcerative colitis (UC) or Crohn's disease (CD) on stable medications were recruited. Blood markers included C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), albumin, platelet count (PLT), and hemoglobin. Fecal biomarkers included fecal calprotectin (FCT) and fecal immunochemical test (FIT). These markers were compared with the endoscopic Mayo score for UC and the Simple Endoscopic Score for CD. One hundred thirteen patients (mean age 44.7 years, 63.7% men, 54.9% patients with UC and 45.1% patients with CD) were recruited. FCT correlated well with FIT (r = 0.58), CRP (r = 0.56), ESR (r = 0.40), albumin (r = -0.54), PLT (r = 0.61), and hemoglobin (r = -0.35; all Ps < 0.001). Among 66 patients with endoscopic evaluation, 39.4% with endoscopically active disease had higher FCT, FIT, CRP, ESR, PLT, lower albumin, and hemoglobin compared with t...Continue Reading

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Citations

Jan 30, 2021·Clinical and Translational Gastroenterology·Natsuki IshidaKen Sugimoto
Nov 3, 2020·World Journal of Gastroenterology : WJG·Rossella GiocoMassimiliano Veroux
Mar 25, 2021·Scientific Reports·Christoph KesselDirk Foell

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ESR

Software Mentioned

R Foundation for Statistical Computing
SPSS
R

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