Combined Use of Ex Vivo Dermoscopy and Histopathology for the Diagnosis of Melanocytic Tumors

The American Journal of Dermatopathology
Joana CabeteAlexandre João

Abstract

Dermoscopy can be applied to fixed tissues, and dermoscopic patterns correlate with microscopic findings. Data on the influence of ex vivo dermoscopy on pathologic diagnosis of melanocytic lesions are limited. Therefore, we aimed to determine whether this technique could aid on the histopathological evaluation of melanocytic neoplasms. Sequential cutaneous excisional biopsies of melanocytic lesions and their corresponding ex vivo dermoscopic images were prospectively analyzed. Additional sectioning was executed in areas of dermoscopic concern, having, by reference, a dermoscopic mapping of the sectioned specimens. Diagnostic differences before and after analyzing the new dermoscopy-guided sections were registered. A total of 564 melanocytic lesions were examined, and additional cuts were considered necessary in 84 (14.9%) cases. Of these, 11 lesions (13.1%) had a different final diagnosis after dermoscopy-guided specimen sectioning, including 3 lesions that were reclassified as melanomas and 2 melanomas that were restaged. We found that the combined use of ex vivo dermoscopy and histopathology improves clinical-pathological correlation and allows selection of representative areas for sectioning. Altogether, this technique may i...Continue Reading

References

Aug 1, 1993·The American Journal of Dermatopathology·S YadavC Grin-Jorgensen
Sep 15, 2001·Dermatologic Clinics·D MassiH P Soyer
Mar 21, 2002·The Lancet Oncology·H KittlerM Binder
Mar 8, 2003·Archives of Dermatology·Ralph Peter BraunJean-Hilaire Saurat
Sep 10, 2003·The American Journal of Surgical Pathology·David B Troxel
Jun 22, 2005·Archives of Dermatology·Senait W DysonStephen Somach
Dec 19, 2007·Archives of Dermatology·Alon ScopeAshfaq A Marghoob
Mar 13, 2008·Journal of Cutaneous Pathology·Saurabh LodhaDavid N Silvers
Mar 23, 2010·Journal of the American Academy of Dermatology·B Aika ShooMohammed Kashani-Sabet
Oct 11, 2011·Journal of the American Academy of Dermatology·Giuseppe ArgenzianoHarald Kittler
Jan 25, 2013·The American Journal of Dermatopathology·Marc HaspeslaghIne De Wispelaere
Jul 19, 2013·JAMA Dermatology·Joseph MalvehySusana Puig
Nov 21, 2013·Journal of Cutaneous Pathology·Lauren N StuartBenjamin K Stoff

❮ Previous
Next ❯

Citations

May 24, 2018·International Journal of Dermatology·Danijela DobrosavljevicDejana Stanisavljevic
Oct 16, 2018·Journal of the American Academy of Dermatology·Oriol YélamosAshfaq A Marghoob

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.