Combined use of F-18 fluorocholine positron emission tomography and magnetic resonance spectroscopy for brain tumor evaluation

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
Sandi A KweeJehoon P Ko

Abstract

Choline metabolism is often abnormal in malignant brain tumors. Brain positron emission tomography (PET) imaging with F-18 fluorocholine (FCH) was performed on 2 patients with intracranial lesions suspected to be high-grade malignant gliomas on the basis of magnetic resonance (MR) imaging and multivoxel 1H-MR spectroscopic imaging (MRSI) findings. Standardized uptake value (SUV) measurements on PET were compared with measurements of choline/creatine metabolite ratio on MRSI in corresponding regions. Brain biopsy revealed glioblastoma multiforme (GBM) in one case and demyelinating disease in the other. In the case of GBM, the tumor demonstrated increased FCH uptake on PET. The mean and maximum SUV in areas of the tumor correlated with regional choline/creatine ratio measurements (r = 0.76, P < .001; r = 0.83, P < .001, respectively). In the case of tumefactive demyelinating lesions, the lesion demonstrated low FCH uptake, which did not correlate with choline/creatine ratio measurements. Assessments of choline metabolism may aid in evaluating intracranial mass lesions.

Citations

Feb 12, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Aditya BansalTimothy R Degrado
May 12, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Sandi Kwee, Thomas Ernst
May 25, 2012·The British Journal of Radiology·Y WaerzeggersA H Jacobs
Nov 3, 2010·Clinical Neurology and Neurosurgery·Winnie Wing-Chuen LamSiew Ju See
Dec 5, 2006·Biochimica Et Biophysica Acta·André A Neves, Kevin M Brindle
Jan 3, 2013·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Julie BolcaenIngeborg Goethals
Oct 9, 2007·Seminars in Nuclear Medicine·Sandi A KweeMarc N Coel
Jun 13, 2019·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Cristina CalsoPhilippe Allain
Feb 16, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Hu-bing WuHong-sheng Li
Apr 17, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Andreas StadlbauerOliver Ganslandt

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