PMID: 9650176Jul 3, 1998Paper

Combined use of FLUKA and MCNP-4A for the Monte Carlo simulation of the dosimetry of 10B neutron capture enhancement of fast neutron irradiations

Medical Physics
J P PignolG Prevot

Abstract

Boron neutron capture enhancement (BNCE) of the fast neutron irradiations use thermal neutrons produced in depth of the tissues to generate neutron capture reactions on 10B within tumor cells. The dose enhancement is correlated to the 10B concentration and to thermal neutron flux measured in the depth of the tissues, and in this paper we demonstrate the feasibility of Monte Carlo simulation to study the dosimetry of BNCE. The charged particle FLUKA code has been used to calculate the primary neutron yield from the beryllium target, while MCNP-4A has been used for the transport of these neutrons in the geometry of the Biomedical Cyclotron of Nice. The fast neutron spectrum and dose deposition, the thermal flux and thermal neutron spectrum in depth of a Plexiglas phantom has been calculated. The thermal neutron flux has been compared with experimental results determined with calibrated thermoluminescent dosimeters (TLD-600 and TLD-700, respectively, doped with 6Li or 7Li). The theoretical results were in good agreement with the experimental results: the thermal neutron flux was calculated at 10.3 X 10(6) n/cm2 s1 and measured at 9.42 X 10(6) n/cm2 s1 at 4 cm depth of the phantom and with a 10 cm X 10 cm irradiation field. For fas...Continue Reading

References

May 1, 1992·Medical Physics·J C YanchR E Klinkowstein
Sep 1, 1992·Medical Physics·D T JonesM J Oliver
Jul 1, 1991·Physics in Medicine and Biology·P Andreo
Jul 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·F PöllerJ Rassow
Mar 1, 1973·Physics in Medicine and Biology·E BlumJ D Heather
May 1, 1995·Physics in Medicine and Biology·D A Allen, T D Beynon
Mar 30, 1994·International Journal of Radiation Oncology, Biology, Physics·G E LaramoreS Brossard
Mar 1, 1993·Physics in Medicine and Biology·F PöllerJ Rassow
May 1, 1996·International Journal of Radiation Oncology, Biology, Physics·R ZamenhofO Harling
Jan 1, 1996·Bulletin du cancer. Radiothérapie : journal de la Société française du cancer : organe de la société française de radiothérapie oncologique·J P PignolN Breteau

❮ Previous
Next ❯

Citations

Feb 13, 2001·International Journal of Radiation Oncology, Biology, Physics·J PignolP Binns
Feb 22, 2003·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine· AslamF E McNeill
Jun 12, 2003·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine· AslamA J Waker
Nov 16, 2001·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·T KatsuK Kataoka
May 10, 2002·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Takashi Katsu, Kazuyuki Ido
Mar 1, 2005·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Takashi KatsuTakehiko Yamato
Sep 6, 2014·Journal of Medical Physics·Keyvan Jabbari, Jan Seuntjens
Feb 8, 2002·Medical Physics·Haijun SongRobert E Klinkowstein
Jun 7, 2000·Medical Physics·A E Schach von WittenauL J Cox
Aug 13, 2021·Physics in Medicine and Biology·Hyojun ParkChul Hee Min

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.