Combined use of heat-shock protein 70 and glutamine synthetase is useful in the distinction of typical hepatocellular adenoma from atypical hepatocellular neoplasms and well-differentiated hepatocellular carcinoma

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Thuy NguyenSanjay Kakar

Abstract

Well-differentiated hepatocellular carcinoma can mimic high-grade dysplastic nodule in cirrhotic liver and hepatocellular adenoma in non-cirrhotic liver. This study evaluates the efficacy of combined use of heat-shock protein 70 (HSP70), glutamine synthetase (GS) and glypican-3 in this setting. Immunohistochemistry for these three markers was done in 17 typical hepatocellular adenoma, 15 high-grade dysplastic nodules, 20 atypical hepatocellular neoplasms (14 clinically atypical and 6 pathologically atypical), 14 very well-differentiated hepatocellular carcinoma, and 43 well-differentiated hepatocellular carcinoma. All three markers were negative in typical adenomas. HSP70 was positive in 10, 71, and 67% of atypical neoplasms, very well-differentiated and well-differentiated HCC, respectively, while GS was positive in 60, 50, and 60% of atypical neoplasms, very well-differentiated and well-differentiated hepatocellular carcinoma, respectively. Glypican-3 was negative in all atypical neoplasms and very well-differentiated hepatocellular carcinoma, and was positive in 27% of well-differentiated hepatocellular carcinoma. Positive staining with at least one marker (HSP70 and/or GS) was seen in 85% of very well-differentiated hepatoc...Continue Reading

References

Dec 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Makoto ChumaSetsuo Hirohashi
Jul 10, 2003·Gastroenterology·Mariana CapurroJorge Filmus
May 28, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Naoko YamauchiMasashi Fukayama
Oct 15, 2005·Journal of Korean Medical Science·Mee JooHyucksang Lee
Jan 13, 2006·The Journal of Biological Chemistry·Kathleen RuchalskiSteven C Borkan
Feb 24, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jessica Zucman-RossiPaulette Bioulac-Sage
Feb 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Luca Di TommasoMassimo Roncalli
Aug 1, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paulette Bioulac-SageJessica Zucman-Rossi
Feb 28, 2008·The American Journal of Surgical Pathology·Wanda M P CostonPeiguo G Chu
Jun 10, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nafis ShafizadehSanjay Kakar
Apr 14, 2012·The American Journal of Surgical Pathology·Aatur D SinghiMichael Torbenson
Jul 4, 2012·Cancer Letters·Anastasia R GoloudinaCarmen Garrido
Jun 29, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nancy M JosephSanjay Kakar
Apr 20, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sanjay KakarLinda D Ferrell

❮ Previous
Next ❯

Citations

May 18, 2016·Clinical and Molecular Hepatology·Massimo RoncalliLuca Di Tommaso
Jan 31, 2017·Seminars in Diagnostic Pathology·Paulette Bioulac-SageCharles Balabaud
Mar 30, 2016·Scientific Reports·Yangyang ChaiMin Zhao
Apr 3, 2020·International Journal of Oncology·Yu-Xue GaoDe-Xi Chen
Sep 27, 2018·World Journal of Gastroenterology : WJG·Archana Rastogi
Jun 26, 2020·Virchows Archiv : an International Journal of Pathology·Andrea JonesRoger K Moreira
Jan 20, 2018·Cancer Control : Journal of the Moffitt Cancer Center·Kun JiangBarbara A Centeno
Oct 2, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Juan PutraPaulette Bioulac-Sage
Mar 11, 2017·Frontiers in Medicine·Luca Di Tommaso, Massimo Roncalli
Feb 10, 2021·The American Journal of Surgical Pathology·Christine SempouxPaulette Bioulac-Sage
Jun 3, 2021·International Journal of Molecular Sciences·Yoshihisa TakahashiToshio Fukusato
Nov 23, 2021·Clinical Journal of Gastroenterology·Tetsuya YasunakaHiroyuki Okada

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenoma, Liver Cell

Liver Cell Adenoma or hepatic adenoma is a rare benign tumor. It is associated with birth control use or pregnancy. Discover the latest research on Liver Cell Adenoma here.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.