Combined use of vitamin D status and FGF23 for risk stratification of renal outcome

Clinical Journal of the American Society of Nephrology : CJASN
Chikako NakanoHiromi Rakugi

Abstract

Hyperphosphatemia, vitamin D deficiency, hyperparathyroidism, and high serum fibroblast growth factor 23 (FGF23) levels, when studied separately, were found to predict the progression of CKD. However, studies with simultaneous measurement of mineral bone disorder (MBD)-related factors were scarce. This study aimed to identify factors predicting renal outcome independent of other factors. This was a prospective cohort study of 738 Japanese predialysis outpatients in the nephrology departments of two hospitals. The outcome was defined as a doubling of serum creatinine or initiation of dialysis. Mean estimated GFR (eGFR) was 35 ml/min per 1.73 m(2). At enrollment, the increase in intact FGF23 with decreasing eGFR was the earliest among changes in MBD-related factors, followed by 1,25-dihydroxyvitamin D decrease, parathyroid hormone increase, and phosphate increase. During a median duration of 4.4 years, 213 patients reached the endpoint. In a multivariable Cox model, high FGF23 and low 25-hydroxyvitamin D (25D) levels were the only MBD-related factors associated with a higher risk of renal endpoint (adjusted hazard ratio [95% confidence interval] per unit change of log FGF23 and 10 ng/ml of 25D: 1.83 [1.28-2.61] and 0.61 [0.41-0.9...Continue Reading

References

Feb 13, 2001·Biochemical and Biophysical Research Communications·N KohY Nabeshima
Jul 20, 2002·Biochemical and Biophysical Research Communications·Tomohide Koizumi Yoshinari Ohnishi
Jul 12, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Thomas J WeberL Darryl Quarles
Feb 26, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·William G GoodmanUNKNOWN Vascular Calcification Work Group
Sep 9, 2006·Journal of the American Society of Nephrology : JASN·Keith C NorrisLawrence J Appel
Sep 19, 2006·Journal of Clinical Epidemiology·A Rogier T DondersKarel G M Moons
Nov 7, 2006·Nature·Itaru UrakawaTakeyoshi Yamashita
Feb 9, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yoshisuke HarunaYashpal S Kanwar
May 22, 2007·Journal of the American Society of Nephrology : JASN·Masahide MizobuchiEduardo Slatopolsky
Jul 28, 2007·Journal of the American Society of Nephrology : JASN·Danilo FliserPeter Riegler
Aug 10, 2007·Kidney International·M WolfR Thadhani
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Stephan SchwarzCsaba P Kovesdy
Nov 10, 2007·The Journal of Clinical Investigation·Iddo Z Ben-DovJustin Silver
Aug 9, 2008·The New England Journal of Medicine·Orlando M GutiérrezMyles Wolf
Sep 23, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Adeera LevinLee Er
Sep 25, 2008·Kidney International·Michael FreundlichBernardo Rodriguez-Iturbe
Oct 10, 2008·Kidney International·Pietro RavaniCarmine Zoccali
Feb 14, 2009·The American Journal of the Medical Sciences·Heng Jung Hsu, Mai-Szu Wu
Mar 20, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Isao MatsuiYoshitaka Isaka
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seiichi MatsuoUNKNOWN Collaborators developing the Japanese equation for estimated GFR
Apr 28, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Guillaume JeanCharles Chazot
Dec 1, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Yan-Ru LouPentti Tuohimaa
Feb 17, 2010·The Journal of Clinical Endocrinology and Metabolism·Justine BacchettaPierre Cochat
Jun 8, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sarah SeilerGunnar H Heine
Oct 23, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Silvia M TitanRosa M A Moysés
Dec 1, 2010·Journal of the American Society of Nephrology : JASN·Ming Chang HuOrson W Moe
Feb 18, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Edward R SmithStephen G Holt
May 27, 2011·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Takayuki HamanoYoshitaka Isaka
Jun 16, 2011·JAMA : the Journal of the American Medical Association·Tamara IsakovaUNKNOWN Chronic Renal Insufficiency Cohort (CRIC) Study Group
Sep 10, 2011·Journal of the American Society of Nephrology : JASN·Jessica KendrickUNKNOWN HOST Investigators

❮ Previous
Next ❯

Citations

Oct 15, 2013·Seminars in Nephrology·Nakshatra Saxena, Orlando M Gutiérrez
Jul 16, 2014·Kidney International Supplements·Takayuki HamanoYoshiharu Tsubakihara
Nov 19, 2015·Kidney International·Howard A Morris
Dec 7, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Javier A NeyraMing Chang Hu
Mar 26, 2013·Expert Opinion on Pharmacotherapy·Masafumi FukagawaTakatoshi Kakuta
Apr 18, 2015·Disease Markers·Yoshitsugu ObiYoshitaka Isaka
Jun 11, 2016·Kidney International·Hirotaka Komaba, Masafumi Fukagawa
Nov 4, 2016·BMC Nephrology·Xiao-Hua LiYun-Hua Liao
Jan 18, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yoshitsugu ObiElani Streja
Oct 14, 2017·The Journal of Clinical Endocrinology and Metabolism·Junichi IshigamiKunihiro Matsushita
Mar 1, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Edward R Smith
Jun 21, 2012·Nature Reviews. Nephrology·Hirotaka Komaba, Masafumi Fukagawa
Nov 29, 2013·The Journal of Clinical Endocrinology and Metabolism·Yoshitsugu ObiYoshiharu Tsubakihara
Nov 21, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Hideaki TakahashiNobukazu Ishizaka
Apr 17, 2020·QJM : Monthly Journal of the Association of Physicians·K SakaiK Tanaka
Sep 17, 2014·Current Opinion in Nephrology and Hypertension·Maarten W Taal
Mar 5, 2016·Hormone Molecular Biology and Clinical Investigation·Masanobu Kawai
Nov 26, 2013·Annals of Clinical Biochemistry·Edward R SmithStephen G Holt
Nov 26, 2015·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Takayuki Hamano
Dec 23, 2017·Clinical and Experimental Nephrology·Takayuki Hamano
Jun 25, 2020·Journal of the American Society of Nephrology : JASN·Junichi IshigamiUNKNOWN CRIC study Investigators
Apr 20, 2017·BioMed Research International·Yoshiko IwasakiMasafumi Fukagawa
Apr 20, 2018·Seminars in Dialysis·Sangeet Dhillon-Jhattu, Stuart M Sprague
Jun 9, 2018·Calcified Tissue International·Yasuto ShikidaTakanori Shibata
Jun 27, 2019·Clinical and Experimental Nephrology·Naoya ToriuYoshifumi Ubara
Dec 13, 2016·Clinical and Experimental Nephrology·Takayuki HamanoYoshitaka Isaka
Apr 19, 2017·Journal of Veterinary Internal Medicine·L M HarjesR E Toribio

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.