Combined wIRA-Hyperthermia and Hypofractionated Re-Irradiation in the Treatment of Locally Recurrent Breast Cancer: Evaluation of Therapeutic Outcome Based on a Novel Size Classification

Cancers
Markus NotterPeter Vaupel

Abstract

Effective tumor control in patients suffering from unresectable locally recurrent breast cancer (LRBC) in pre-irradiated areas can be achieved by re-irradiation combined with superficial hyperthermia. Using this combined modality, total re-irradiation dose and toxicity can be significantly reduced compared to conventionally fractionated treatment schedules with total doses of 60-66 Gy. Applying contact-free, thermography-controlled water-filtered infrared-A superficial hyperthermia, immediately followed by hypofractionated re-irradiation, consisting of 4 Gy once per week up to a total dose of 20 Gy, resulted in high overall response rates even in large-sized tumors. Comparability of clinical data between different combined Hyperthermia (HT)/Radiotherapy (RT) treatment schedules is impeded by the highly individual characteristics of this disease. Tumor size, ranging from microscopic disease and small lesions to large-sized cancer en cuirasse, is described as one of the most important prognostic factors. However, in clinical studies and analyses of LRBC, tumor size has so far been reported in a very heterogeneous way. Therefore, we suggest a novel, simple and feasible size classification (rClasses 0-IV). Applying this classificat...Continue Reading

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Citations

May 6, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Alexander RühleNils H Nicolay
Jul 22, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Helmut PiazenaPeter Vaupel
Aug 13, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Philipp KlemmUwe Lange
Sep 9, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andreas R ThomsenMarkus Notter
Sep 9, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas A BuchholzKelly K Hunt
Dec 21, 2020·Journal of Radiation Research·Hideya YamazakiUNKNOWN JReRT Group
Jan 21, 2021·Integrative Cancer Therapies·Markus NotterPeter Vaupel
Jan 29, 2021·Advances in Radiation Oncology·Sayeh FattahiKimberly S Corbin
Apr 4, 2021·Cancers·Johannes CrezeeArlene L Oei

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