PMID: 9439159Jun 1, 1997Paper

Combining ADA, protein and IFN-gamma best allows discrimination between tuberculous and malignant pleural effusion

The Korean Journal of Internal Medicine
Y C KimJ H Park

Abstract

The purpose of this study is to assess the usefulness of various enzymes, cytokines and biochemical studies of pleural fluid for the differential diagnosis of tuberculosis from malignant pleural effusions, and to clarify the role of combining diagnostic tests. The study group included 39 cases with tuberculous effusions and 31 cases with malignant effusions, whose diagnoses were confirmed by pleural biopsy, cytology or microbiological methods. We compared pleural fluid levels of ADA, TNF-alpha, IFN-gamma, IL-2, IL-6, IL-8, pH, protein, glucose, cholesterol, triglyceride, amylase and lactic dehydrogenase between tuberculous and malignant effusions. Using stepwise logistic regression analysis, we evaluated the benefit of combining various parameters. Receiver operating characteristic(ROC) curves of ADA, cytokines and equations generated from regression analyses were plotted and compared with the area under curve(AUC). Cut-off values showing the best diagnostic accuracy were selected and compared. Compared to malignant effusion, tuberculous effusion showed significantly higher levels of ADA, IFN-gamma, TNF-alpha and IL-2. There was a good correlation between IFN-gamma and TNF-alpha. By stepwise logistic regression analysis, IFN-ga...Continue Reading

References

Jul 1, 1991·The Korean Journal of Internal Medicine·N J KimH K Ro
Oct 1, 1972·Annals of Internal Medicine·R W LightW C Ball
Feb 1, 1994·Cytopathology : Official Journal of the British Society for Clinical Cytology·H G De OliveiraJ C Prolla
Apr 1, 1993·Clinical and Experimental Immunology·J MaedaK Higashino

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Citations

Nov 22, 2008·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Akihiro ShirakabeKyoichi Mizuno
Feb 24, 2004·Asian Cardiovascular & Thoracic Annals·Mostafa GhaneiHossein Adhami
Feb 26, 2004·Respirology : Official Journal of the Asian Pacific Society of Respirology·Enas A HamedAzza Mahmoud
Nov 20, 2020·Journal of Clinical Microbiology·Ashutosh Nath AggarwalValliappan Muthu

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