Combining C-reactive protein and interleukin-6 may be useful to detect periprosthetic hip infection.

Clinical Orthopaedics and Related Research
Martin A ButtaroFrancisco Piccaluga

Abstract

The sensitivity and specificity to detect periprosthetic infection of the different methods have been questioned, and no single laboratory test accurately detects infection before revision arthroplasty. We asked whether preoperative C-reactive protein (CRP) and interleukin-6 (IL-6) could lead to similar sensitivity, specificity, and predictive values as our previous results obtained with intraoperative frozen section (FS) in revision total hip arthroplasty (THA). We prospectively followed 69 patients who had undergone revision THA for failure of a primary THA. The definitive diagnosis of an infection was determined on the basis of positive histopathologic evidence of infection or growth of bacteria on culture. Eleven of the 69 hips were infected. The combination of an elevated CRP and IL-6 was correlated with deep infection in all the cases and showed a sensitivity of 0.57 (0.13-1.00), a specificity of 1.00 (0.99-1.00), a positive predictive value of 1.00 (0.87-1.00), and a negative predictive value of 0.94 (0.87-1.00). FS showed a sensitivity of 0.81 (0.54-1.00), a specificity of 0.98 (0.94-1.00), a positive predictive value of 0.90 (0.66-1.00), and a negative predictive value of 0.96 (0.91-1.00). Combining CRP and IL-6 provid...Continue Reading

References

Mar 1, 1992·The Journal of Bone and Joint Surgery. British Volume·P RobertsD J McMinn
Feb 1, 1990·The Biochemical Journal·P C HeinrichT Andus
Jan 1, 1993·The Journal of Bone and Joint Surgery. American Volume·R L Barrack, W H Harris
Aug 1, 1995·The Journal of Arthroplasty·D E PadgettJ O Galante
Dec 1, 1995·The Journal of Bone and Joint Surgery. American Volume·D S FeldmanJ D Zuckerman
Aug 1, 1996·The Journal of Arthroplasty·T K Fehring, B Cohen
Oct 1, 1996·The Journal of Bone and Joint Surgery. American Volume·J H LonnerJ D Zuckerman
Nov 18, 2000·International Orthopaedics·D C WirtzJ M Wolff
Aug 2, 2002·Clinical Orthopaedics and Related Research·Daxes M BanitJames M Hartford
Sep 6, 2005·The Journal of Bone and Joint Surgery. American Volume·Paul E Di CesareChuan-ju Liu
Jan 30, 2007·The Journal of Bone and Joint Surgery. British Volume·F BottnerC Götze
Apr 28, 2007·Acta Orthopaedica·Leandro V NuñezFrancisco Piccaluga
Sep 3, 2008·The Journal of Bone and Joint Surgery. American Volume·Mark F SchinskyWayne G Paprosky
Jan 6, 2009·The Journal of Bone and Joint Surgery. American Volume·Kevin J BozicDaniel J Berry
Sep 22, 2009·Clinical Orthopaedics and Related Research·Stephan W TohtzCarsten Perka

❮ Previous
Next ❯

Citations

Jun 28, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Wolfram KoppensteinerGabriele Halwachs-Baumann
Dec 12, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Douglas R OsmonUNKNOWN Infectious Diseases Society of America
Aug 20, 2014·The Journal of Antimicrobial Chemotherapy·Kordo Saeed
Oct 13, 2015·Case Reports in Orthopedics·Juan Felix Astoul BonorinoLisandro Carbó
Apr 15, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Max EttingerAlexander Lukasz
Apr 18, 2018·JBJS Reviews·Chun Hoi YanJavad Parvizi
Aug 15, 2014·International Orthopaedics·Adham ElgeidiShirien Rakha
May 28, 2015·Clinical Orthopaedics and Related Research·Martin A ButtaroFrancisco Piccaluga
Jan 24, 2020·The Journal of the American Academy of Orthopaedic Surgeons·Creighton C TubbBarbara Krause
Sep 6, 2020·Journal of Orthopaedic Surgery and Research·Qiao JiangJi-Ying Chen
Apr 11, 2014·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Jonathan BuchheitPatrick Garbuio
Jul 28, 2019·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Isaac Majors, Vivek S Jagadale
Jun 17, 2020·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Lucas LuyckxLore Hermans
Oct 4, 2020·Journal of Orthopaedic Surgery and Research·Cheng LiAndrej Trampuz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.