Combining CA 125 and SMR serum markers for diagnosis and early detection of ovarian carcinoma

Gynecologic Oncology
Martin W McIntoshIngegerd Hellstrom

Abstract

The serum tumor marker CA 125 is elevated in most clinically advanced ovarian carcinomas. Because these elevations may precede clinical detection by a year or more, CA 125 is potentially useful for early detection as part of an ovarian cancer screening program. However, CA 125 is often not elevated in clinically detected cancer and is frequently elevated in women with benign ovarian tumors. CA 125 may be more useful in conjunction with one or more other tumor biomarkers. Additional markers could play a role if, when used with CA 125, they identify some carcinomas missed by CA 125 (i.e., they improve sensitivity), rule out false positives (i.e., improve specificity), or are able to detect the same cancers earlier. We have evaluated a composite marker (CM) that combines CA 125 and a previously described soluble mesothelin related (SMR) marker in sera from 52 ovarian cancer cases, 43 controls with benign ovarian tumors, and 220 normal risk controls who participated in a screening program, including 25 healthy women having two serum samples collected 1 year apart. CA 125, SMR, and CM were evaluated for their ability to identify clinical disease and for their temporal stability, which assesses their ability to obtain even greater se...Continue Reading

References

Feb 1, 1992·International Journal of Cancer. Journal International Du Cancer·K ChangM C Willingham
Jan 1, 1991·Journal of Clinical Epidemiology·S J Skates, D E Singer
Sep 15, 1995·The Journal of Biological Chemistry·T KojimaN Yamaguchi
Apr 1, 1994·International Journal of Cancer. Journal International Du Cancer·K Chang, I Pastan
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·N SchollerI Hellström
Sep 17, 2002·Biometrics·Martin W McIntosh, Margaret Sullivan Pepe

❮ Previous
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Citations

Dec 13, 2006·Future Oncology·Zoya R YurkovetskyAnna E Lokshin
May 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Gil MorDavid C Ward
May 17, 2011·Journal of Proteomics·Jung-min LeeElise C Kohn
Nov 1, 2005·Women's Health·Nana E TchaboElise C Kohn
Sep 1, 2006·Women's Health·Nicole Urban, Charles Drescher
Mar 13, 2013·Women's Health·Long NguyenDavid Fishman
Apr 13, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nathalie SchollerNicole Urban
Jul 28, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·G S LeiserowitzK S Lam
May 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nathalie SchollerNicole Urban
Jul 26, 2008·Journal of Translational Medicine·Nathalie SchollerNicole Urban
Aug 30, 2008·Biostatistics·Ying Huang, Margaret Sullivan Pepe
Sep 5, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kimberly A LoweCharles W Drescher
May 9, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Chirag A ShahCharles W Drescher
Oct 22, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fabian Mc JohnstonPeter Goedegebuure
Jan 1, 2010·Journal of the National Cancer Institute·Garnet L AndersonNicole Urban
Apr 7, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Zoya YurkovetskyAnna E Lokshin
Jun 1, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Janneta TcherkassovaRicardo Moro
Aug 19, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Judith L LuborskyIngegerd Hellstrom
Oct 6, 2005·Nature Clinical Practice. Oncology·Martin McIntosh
Jun 1, 2008·Biomarkers in Medicine·Partha M Das, Robert C Bast
Aug 18, 2009·Biomarkers in Medicine·Dimitra SasaroliNathalie Scholler
Apr 2, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Emanuela AnastasiMaria Gabriella Reale
Apr 2, 2013·Indian Journal of Clinical Biochemistry : IJCB·Kannan Vaidyanathan, D M Vasudevan
Dec 14, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·R C BastK Lu
May 10, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M L DisisJ S Berek
Oct 14, 2005·The New England Journal of Medicine·Harvey I PassAnil Wali
Feb 4, 2006·American Journal of Respiratory and Critical Care Medicine·Arnaud ScherpereelPhilippe Lassalle
Oct 9, 2009·Expert Review of Proteomics·Shengnan XieS Patrick Walton
Sep 17, 2010·Expert Review of Molecular Diagnostics·Juan RenShi-Wen Jiang
Sep 10, 2005·Expert Review of Molecular Diagnostics·Sorin DraghiciMichael A Tainsky
Feb 10, 2007·Expert Review of Proteomics·Bin YeSamuel C Mok
May 1, 2009·Expert Opinion on Medical Diagnostics·Brian Keith McNeil, Robert H Getzenberg
Sep 1, 2007·Expert Opinion on Medical Diagnostics·Zhong-Qian LiW Jeffrey Allard
Jun 7, 2011·Expert Opinion on Medical Diagnostics·Ingegerd Hellstrom, Karl Erik Hellstrom
Jul 25, 2007·Chest·Jenette CreaneyBruce W S Robinson
Jan 29, 2016·BioMed Research International·Oleg BlyussJohn F Timms
Dec 1, 2009·Gynecologic Oncology·M Robyn AndersenNicole Urban
Jun 7, 2007·Mayo Clinic Proceedings·Giovanni D AlettiLynn C Hartmann
Feb 19, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Oluf Dimitri RoeKristina Kjaerheim
Jan 16, 2013·Journal of Oncology·Sreeja SarojiniK Stephen Suh
Aug 18, 2005·American Journal of Reproductive Immunology : AJRI·Judith L LuborskyJacob Rotmensch

❮ Previous
Next ❯

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