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Combining Classical MD and QM calculations to elucidate complex system nucleation: a twisted, three-stranded, parallel β-sheet seeds amyloid fibril conception

The Journal of Physical Chemistry. B

Jun 12, 2014

Miguel MompeánDouglas V Laurents

Abstract

The crystal structure of the Sup35 prion segment, GNNQQNY, revealed precise side chain packing and an extensive H-bond network. However, the conformers and stabilizing interactions involved at nascent amyloid formation are still unclear. Here, long molecular dynamics simulations and qua...read more

Mentioned in this Paper

Thermodynamics
Molecular Dynamics
Gait, Drop Foot
APP protein, human
Protein NMR Spectroscopy
Cell Nucleus
Quantum Theory
Epidermolysa Bullosa Simplex and Limb Girdle Muscular Dystrophy
Amyloid Deposition
Amyloid
1
23
Paper Details
References
  • References17
  • Citations11
12
  • References17
  • Citations11
12

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Combining Classical MD and QM calculations to elucidate complex system nucleation: a twisted, three-stranded, parallel β-sheet seeds amyloid fibril conception

The Journal of Physical Chemistry. B

Jun 12, 2014

Miguel MompeánDouglas V Laurents

PMID: 24918329

DOI: 10.1021/jp503742p

Abstract

The crystal structure of the Sup35 prion segment, GNNQQNY, revealed precise side chain packing and an extensive H-bond network. However, the conformers and stabilizing interactions involved at nascent amyloid formation are still unclear. Here, long molecular dynamics simulations and qua...read more

Mentioned in this Paper

Thermodynamics
Molecular Dynamics
Gait, Drop Foot
APP protein, human
Protein NMR Spectroscopy
Cell Nucleus
Quantum Theory
Epidermolysa Bullosa Simplex and Limb Girdle Muscular Dystrophy
Amyloid Deposition
Amyloid
1
23

Similar Papers Found In These Feeds

Prion Disease: Cholesterol

The Prion Disease: Cholesterol feed describes the role cholesterol plays in the conversion and transmission of prion. Discover the latest research on the role of cholesterol in prion disease here.

Alzheimer's Disease: APP

Amyloid precursor protein proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques. Here is the latest research.

Related Papers

The FEBS Journal

The prion protein binds thiamine

The FEBS JournalAugust 19, 2011
Rolando Perez-PineiroDavid S Wishart
Paper Details
References
  • References17
  • Citations11
12
  • References17
  • Citations11
12
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