Combining Gene Transfer and Nonhuman Primates to Better Understand and Treat Parkinson's Disease

Frontiers in Molecular Neuroscience
Christelle LasbleizJean-Michel Verdier

Abstract

Parkinson's disease (PD) is a progressive CNS disorder that is primarily associated with impaired movement. PD develops over decades and is linked to the gradual loss of dopamine delivery to the striatum, via the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). While the administration of L-dopa and deep brain stimulation are potent therapies, their costs, side effects and gradual loss of efficacy underlines the need to develop other approaches. Unfortunately, the lack of pertinent animal models that reproduce DA neuron loss and behavior deficits-in a timeline that mimics PD progression-has hindered the identification of alternative therapies. A complementary approach to transgenic animals is the use of nonhuman primates (NHPs) combined with the overexpression of disease-related genes using viral vectors. This approach may induce phenotypes that are not influenced by developmental compensation mechanisms, and that take into account the personality of animals. In this review article, we discuss the combination of gene transfer and NHPs to develop "genetic" models of PD that are suitable for testing therapeutic approaches.

References

Apr 26, 2001·Molecular Therapy : the Journal of the American Society of Gene Therapy·C SoudaisE J Kremer
Aug 21, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C SoudaisE J Kremer
Jun 21, 2002·Human Molecular Genetics·E Martin-TouauxL Poenaru
Aug 6, 2002·Neuron·Ted DawsonMichael Lee
Feb 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Deniz KirikAnders Björklund
Oct 27, 2004·Cell and Tissue Research·Andreas Schober
Jun 11, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·S GoverdhanaM G Castro
Jun 16, 2005·Neurobiology of Aging·Marine JolyJean-Michel Verdier
Nov 7, 2006·Experimental Gerontology·Jean-Luc Picq
Aug 23, 2007·ILAR Journal·Marina E Emborg
Oct 24, 2007·Experimental Neurology·Marie-Francoise Chesselet
Nov 21, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Nobutaka Hattori, Shigeto Sato
Jan 25, 2008·Journal of Virology·Guy SchoehnEric J Kremer
Jul 28, 2009·Expert Reviews in Molecular Medicine·Thomas Gasser
Apr 21, 2010·Neurobiology of Learning and Memory·Stéphanie G TroucheNadine Mestre-Francés
Jun 16, 2010·Neuron·Ted M DawsonValina L Dawson
Aug 14, 2010·Nature Reviews. Microbiology·Sara SalinasEric J Kremer
Oct 26, 2010·Neurobiology of Aging·Jean-Luc PicqMarc Dhenain
Jan 21, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Julien DusonchetPatrick Aebischer
Feb 16, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Raymond T BartusJeffrey H Kordower
Jun 24, 2011·International Journal of Biological Sciences·Hongxia ZhouXu-Gang Xia
Aug 2, 2011·Ageing Research Reviews·S LanguilleF Aujard
Jan 21, 2012·Emerging Infectious Diseases·Nadine Mestre-FrancésJean-Michel Verdier
Feb 9, 2012·Cold Spring Harbor Perspectives in Medicine·Christine Klein, Ana Westenberger
Apr 24, 2012·Glycobiology·Christoph RademacherJames C Paulson
Jul 4, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Erwan BezardMaria Grazia Spillantini

❮ Previous
Next ❯

Citations

May 30, 2019·Rejuvenation Research·Andrew R Mendelsohn, James W Larrick
Apr 16, 2019·Frontiers in Molecular Neuroscience·Danila Del RioEric J Kremer
Apr 10, 2020·Frontiers in Molecular Neuroscience·Carla di CaudoRosario Luquin
Jun 6, 2020·Frontiers in Molecular Neuroscience·Anne-Caroline MartelPaul Apicella
Jul 11, 2020·Neurobiology of Aging·Daniel SchmidtkeNadine Mestre-Francés

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
GTPase

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

Antioxidants & Redox Signaling
Terina N Martinez, J Timothy Greenamyre
Journal of Controlled Release : Official Journal of the Controlled Release Society
Jodie H K ManMassimiliano Caiazzo
La Revue de médecine interne
V Fraix
© 2022 Meta ULC. All rights reserved