Combining GFR estimates from cystatin C and creatinine-what is the optimal mix?

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Emil den BakkerArend Bökenkamp

Abstract

Combining estimated glomerular filtration rate (eGFR) equations based on creatinine and cystatin C has been shown to improve the accuracy of GFR estimation. This study aims to optimize this strategy for height-independent GFR estimation in children. Retrospective study of 408 inulin clearance tests with simultaneous International Federation of Clinical Chemistry-calibrated measurements of creatinine, cystatin C, and urea in children (mean age 12.5 years, GFR 91.2 ml/min/1.73m2) comparing the arithmetic (meanarith) and geometric means (meangeom) of a height-independent creatinine-based (full age spectrum, based on age (FASage)) and a cystatin C-based equation (FAScys), with the complex height-dependent CKiD3 equation incorporating gender, height, cystatin C, creatinine, and urea. Meangeom had a P30 accuracy of 89.2% compared to meanarith 87.7% (p = 0.030) as well as lower bias and %precision error and performed almost as well as CKiD3 (P30 accuracy 90.9%). Modifying the weight of FASage and FAScys when calculating the means showed that an equal contribution was most accurate in most patients. In spina bifida patients, FAScys alone outperformed any combination. Malignancy or nephritis patients had slightly higher accuracy with we...Continue Reading

References

Nov 15, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Suzuki, M Yoshida
Nov 1, 1995·Scandinavian Journal of Clinical and Laboratory Investigation·M BjarnadóttirI Olafsson
Apr 16, 1998·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A BökenkampJ Brodehl
Aug 26, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·H ManggeW Erwa
Aug 16, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Guido Filler, Nathalie Lepage
Oct 22, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Uwe PögeRainer P Woitas
Dec 6, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·U PögeR P Woitas
Jul 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michael ZappitelliLorraine Bell
Feb 1, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Alessandra Calábria BaxmannIta Pfeferman Heilberg
Feb 13, 2008·Clinical Chemistry·Arend BökenkampBirgit Stoffel-Wagner
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Sep 10, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Florian BrinkertRainer Ganschow
Nov 3, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Anders GrubbUNKNOWN IFCC Working Group on Standardisation of Cystatin C (WG-SCC)
Nov 30, 2011·Scandinavian Journal of Clinical and Laboratory Investigation·Anders GrubbJonas Björk
Dec 18, 2012·Journal of Pediatric Hematology/oncology·Meera RayarRonald D Barr
Feb 2, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Rik WestlandJoanna A E van Wijk
Sep 21, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Liesbeth HosteHans Pottel
Nov 21, 2013·Clinical and Experimental Nephrology·Osamu UemuraMasataka Honda
Oct 3, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Jonas BjörkUlf Nyman
Mar 2, 2016·Archives of Pathology & Laboratory Medicine·Lenard Mueller, Claus Pruemper
Mar 5, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hans PottelPierre Delanaye
Mar 30, 2017·Clinical Chemistry·K G E van RoijA Bökenkamp
Sep 10, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Emil den BakkerArend Bökenkamp
Dec 9, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Guido Filler, Misan Lee
Feb 2, 2018·Critical Reviews in Clinical Laboratory Sciences·Emil den BakkerArend Bökenkamp
Mar 4, 2018·Advances in Chronic Kidney Disease·Hans PottelPierre Delanaye

❮ Previous
Next ❯

Citations

Feb 5, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jonas BjörkHans Pottel
Mar 12, 2019·The Cochrane Database of Systematic Reviews·Esmee Cm KooijmansMargreet A Veening
Nov 23, 2019·Scandinavian Journal of Clinical and Laboratory Investigation·Emil den BakkerArend Bökenkamp
Sep 2, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Cathrin L SalvadorLars Mørkrid
Jan 19, 2021·Scandinavian Journal of Clinical and Laboratory Investigation·Emil den BakkerArend Bokenkamp
Jan 12, 2021·Critical Care Research and Practice·Bita ShahramiMojtaba Mojtahedzadeh
Mar 12, 2021·European Journal of Pediatrics·Julie Mouron-HryciukHassib Chehade
Aug 5, 2021·Clinical Kidney Journal·Natalie EbertElke Schaeffner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinica Chimica Acta; International Journal of Clinical Chemistry
Emil den BakkerArend Bökenkamp
Clinica Chimica Acta; International Journal of Clinical Chemistry
Emil den BakkerArend Bökenkamp
© 2022 Meta ULC. All rights reserved