PMID: 16635326Apr 26, 2006Paper

Combining high-risk human papillomavirus DNA test and cytological test to detect early cervical dysplasia

Zhonghua fu chan ke za zhi
De-ying QianZhi-hong Huang

Abstract

To assess the value of combining high-risk human papillomavirus (HPV) DNA test and cytological test in detection of early cervical dysplasia. During January 2003 to June 2004, a total of 5210 women were screened by combining high-risk HPV DNA test (hybrid capture II, HC-II) and cytological test (liquid-based ThinPrep cytology test), and the abnormal cytological or HPV DNA findings were further biopsied under the colposcope. The age of the patients was between 17 to 80, the average was 34 +/- 9. Final pathological diagnosis was HPV infection in 890 cases, cervical intraepithelial neoplasia (CIN) I in 83 cases, CIN II in 73 cases, CIN III in 80 cases, invasive cervical cancer in 54 cases, endometrial cancer in 5 cases, vaginal intraepithelial neoplasia in 1 case and cervical tuberculosis in 1 case. Based on the criteria of histology and pathology, the sensitivity, specificity, positive-predictive value and negative-predictive value of high-risk HPV DNA test for detecting all cases of CIN II, III were 92.22%, 74.71%, 5.19% and 99.84% respectively. In detecting all cases of CIN II, III by cytological test, for atypical squamous cell of undetermined signification (ASCUS), the sensitivity, specificity, positive-predictive value and n...Continue Reading

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Journal of Insurance Medicine
Charlotte A Lee
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA
Guo-Bing LiuFu-Qi Xing
International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Maria NasioutzikiPetros Karakitsos
The Australian & New Zealand Journal of Obstetrics & Gynaecology
Sun-Kuie Tay, Yeng-Kwang Tay
© 2022 Meta ULC. All rights reserved