Combining image-derived and venous input functions enables quantification of serotonin-1A receptors with [carbonyl-11C]WAY-100635 independent of arterial sampling

NeuroImage
Andreas HahnRupert Lanzenberger

Abstract

image- derived input functions (IDIFs) represent a promising technique for a simpler and less invasive quantification of PET studies as compared to arterial cannulation. However, a number of limitations complicate the routine use of IDIFs in clinical research protocols and the full substitution of manual arterial samples by venous ones has hardly been evaluated. This study aims for a direct validation of IDIFs and venous data for the quantification of serotonin-1A receptor binding (5-HT(1A)) with [carbonyl-(11)C]WAY-100635 before and after hormone treatment. Fifteen PET measurements with arterial and venous blood sampling were obtained from 10 healthy women, 8 scans before and 7 after eight weeks of hormone replacement therapy. Image-derived input functions were derived automatically from cerebral blood vessels, corrected for partial volume effects and combined with venous manual samples from 10 min onward (IDIF+VIF). Corrections for plasma/whole-blood ratio and metabolites were done separately with arterial and venous samples. 5-HT(1A) receptor quantification was achieved with arterial input functions (AIF) and IDIF+VIF using a two-tissue compartment model. Comparison between arterial and venous manual blood samples yielded ex...Continue Reading

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Citations

Nov 16, 2013·Experimental Brain Research·Mohammad Hadi GharedaghiReza Rahimian
Nov 28, 2012·Wiener klinische Wochenschrift·Andreas Hahn
Jan 24, 2014·International Journal of Molecular Imaging·Mike SattarivandCurtis Caldwell
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Apr 18, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Giampaolo TomasiKathleen C Schmidt
Jun 13, 2018·EJNMMI Research·Colm J McGinnityAlexander Hammers
Jul 9, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Andreas HahnRupert Lanzenberger

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