Combining in vitro and in silico Approaches to Find New Candidate Drugs Targeting the Pathological Proteins Related to the Alzheimer's Disease

Current Neuropharmacology
Hui LiZhaogang Yang

Abstract

Alzheimer's disease (AD) as the most common cause of dementia among older people has aroused the universal concern of the whole world. However, until now there is still none effective treatments. Consequently, the development of new drugs targeting this complicated brain disorder is urgent and needs more efforts. In this review, we detailed the current state of knowledge about new candidate drugs targeting the pathological proteins especially the drugs which are employed using the combined methods of in vitro and in silico. We looked up and reviewed online papers related to the pathogenesis and new drugs development of AD. Then, articles up to the requirements were respectively analyzed and summaried to provide the latest knowledge about the pathogenic effect and the new candidate drugs targeting Aβ and Tau proteins. New candidate drugs targeting the Aβ include decreasing the production, promoting the clearence and preventing aggregation. However these drugs have mostly failed in Phase III clinical trial stage due to the unsuccessful of reversing cognition symptoms. As to tau protein, the prevention of tau aggregation and propagation is a promising strategy to synthesize/design mechanismbased drugs against tauopathies. Some can...Continue Reading

Citations

Nov 21, 2019·Clinical and Experimental Pharmacology & Physiology·Wasim AhmadIbraheem Husain
Apr 25, 2020·Diabetes Care·R Brett McQueenMarian Rewers
Sep 16, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Haiwa WuJingyao Sun
Aug 31, 2020·Dose-response : a Publication of International Hormesis Society·Guichen LiDongming Wang
Feb 8, 2020·Dose-response : a Publication of International Hormesis Society·Jinqiao WangHongjuan Li
Jul 9, 2020·Dose-response : a Publication of International Hormesis Society·You ZhouHaopeng Sun
May 20, 2020·Dose-response : a Publication of International Hormesis Society·Jinqiao WangChaohong Shi

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Methods Mentioned

BETA
transgenic
in silico methods

Software Mentioned

SPROUT

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