Combining intraoperative carmustine wafers and Stupp regimen in multimodal first-line treatment of primary glioblastomas

British Journal of Neurosurgery
Vladislav PavlovJohan Pallud

Abstract

The study investigated if intraoperative use of carmustine wafers, particularly in combination with Stupp regimen, is a viable and safe first-line treatment option of glioblastomas. Eighty-three consecutive adult patients (50 men; mean age 60 years) with newly diagnosed supratentorial primary glioblastomas that underwent surgical resection with intraoperative carmustine wafers implantation (n = 7.1 ± 1.7) were retrospectively studied. The median overall survival (OS) was 15.8 months with 56 patients dying over the course of the study. There was no significant association between the number of implanted carmustine wafers and complication rates (four surgical site infections, one death). The OS was significantly longer in Stupp regimen patients (19.5 months) as compared with patients with other postoperative treatments (13 months; p = 0.002). In addition patients with eight or more implanted carmustine wafers survived longer (24.5 months) than patients with seven or less implanted wafers (13 months; p = 0.021). Finally, regardless of the number of carmustine wafers, median OS was significantly longer in patients with a subtotal or total resection (21.5 months) than in patients with a partial resection (13 months; p = 0.011). The ...Continue Reading

References

Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Jun 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·René-Olivier MirimanoffRoger Stupp
Mar 6, 2007·Acta neurochirurgica·J M GallegoC Barcia-Mariño
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Oct 14, 2008·Journal of Neurosurgery·Matthew J McGirtAlf Redo Quiñones-Hinojosa
Dec 3, 2008·Journal of Neurosurgery·Matthew J McGirtAlfredo Quiñones-Hinojosa
May 6, 2010·Annals of Surgical Oncology·Philippe MeneiUNKNOWN Neuro-oncology Club of the French Society of Neurosurgery
Mar 23, 2011·Journal of Neurosurgery·Nader SanaiMitchel S Berger
Jul 26, 2011·Annals of Neurology·Matthias PreusserRoger Stupp
Jun 22, 2012·British Journal of Neurosurgery·James Geoffrey Barr, Paul L Grundy
Jun 22, 2012·Acta neurochirurgica·Pasquale De BonisAnnunziato Mangiola

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Citations

Jul 18, 2015·Neuro-oncology·Johan PalludUNKNOWN Club de Neuro-Oncologie of the Société Française de Neurochirurgie
Sep 26, 2017·Future Oncology·Clément DupontMaximilien Vermandel
May 10, 2017·Molecular Cytogenetics·Steffi UrbschatRalf Ketter
Jun 17, 2019·Revue neurologique·A RouxJ Pallud

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