Combining Lactate Dehydrogenase and Fibrinogen: Potential Factors to Predict Therapeutic Efficacy and Prognosis of Patients with Small-Cell Lung Cancer.

Cancer Management and Research
Wen HuangWei-Ping Xie

Abstract

A growing interest exists in identifying reliable and low-cost biomarkers or factors that could predict the therapeutic response, prognosis, recurrence, and survival in small-cell lung cancer (SCLC). This study aimed to investigate the better predictors of chemotherapy efficacy and prognosis in patients with SCLC receiving first-line chemotherapy and radiotherapy. This study retrospectively retrieved the medical records of patients with SCLC treated with first-line platinum-based chemotherapy and radiotherapy from January 2016 to June 2019 in the First Affiliated Hospital of Nanjing Medical University. Plasma biochemical parameters, clinical features, and overall survival (OS) time were collected. The independent effects of plasma parameters on patient survival were assessed by conducting univariate and multivariate Cox regression analyses. The optimal cut-off values of independent risk factors in the ROC curve and Kaplan-Meier survival analysis were determined using MedCalc software. Statistically significant differences in lactate dehydrogenase (LDH) and fibrinogen (Fbg) were found between the complete remission + partial remission group and the non-responders, which consisted of stable-disease and progressive-disease groups,...Continue Reading

References

Jan 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G BuccheriC Zuliani
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Aug 17, 2005·Journal of Thrombosis and Haemostasis : JTH·M W Mosesson
Jul 25, 2008·Nature·Alberto MantovaniFrances Balkwill
Sep 26, 2008·The New England Journal of Medicine·Roy S HerbstScott M Lippman
Jun 12, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Takashi HiroseMitsuru Adachi
Dec 22, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yao-Wen KuoPan-Chyr Yang
Jan 25, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Jong-Ryool OhHee-Seung Bom
Jun 26, 2013·Biochimica Et Biophysica Acta·Marjan HarmsmaFrans C S Ramaekers
Jul 18, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·L-R ZhuX-P Tang
Nov 7, 2015·The European Respiratory Journal·Y NilssenB Møller
Apr 12, 2016·Cancer Biomarkers : Section a of Disease Markers·Xiuxiu ZhangYang Jin
Jan 21, 2017·Molecular and Clinical Oncology·Suoyuan LiYingqi Hua
Aug 26, 2017·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Stefan DiemMartin Früh
Jul 30, 2019·Cancer Biomarkers : Section a of Disease Markers·Xiaolu RenXuejun Liu

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Software Mentioned

MedCalc
SPSS

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