Combining measurements from three anatomical areas for glaucoma diagnosis using Fourier-domain optical coherence tomography

The British Journal of Ophthalmology
Nils A LoewenAdvanced Imaging for Glaucoma Study Group

Abstract

To improve the diagnostic power for glaucoma by combining measurements of peripapillary nerve fibre layer (NFL), macular ganglion cell complex (GCC) and disc variables obtained with Fourier-domain optical coherence tomography (FD-OCT) into the glaucoma structural diagnostic index (GSDI). In this observational, cross-sectional study of subjects from the Advanced Imaging of Glaucoma Study, GCC and NFL of healthy and perimetrical glaucoma subjects from four major academic referral centres of the Advanced Imaging of Glaucoma Study were mapped with the RTVue FD-OCT. Global loss volume and focal loss volume parameters were defined using NFL and GCC normative reference maps. Optimal weights for NFL, GCC and disc variables were combined using multivariate logistic regression to build the GSDI. Glaucoma severity was classified using the Enhanced Glaucoma Staging System (GSS2). Diagnostic accuracy was assessed by sensitivity, specificity and the area under the receiver operator characteristic curve (AUC). We analysed 118 normal eyes of 60 subjects, 236 matched eyes of 166 subjects with perimetrical glaucoma, and 105 eyes from a healthy reference group of 61 subjects. The GSDI included composite overall thickness and focal loss volume wit...Continue Reading

Associated Clinical Trials

Mar 14, 2011·David Huang

References

Dec 26, 2001·Archives of Ophthalmology·H A QuigleyR Snyder
Dec 27, 2005·Journal of Glaucoma·Paolo Brusini, Stefano Filacorda
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Jan 18, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Andreas SchulzeEsther M Hoffmann
Jan 20, 2011·Investigative Ophthalmology & Visual Science·Brian A FrancisUNKNOWN Los Angeles Latino Eye Study Group
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Jul 26, 2012·Journal of Glaucoma·Mingwu WangUNKNOWN Advanced Imaging for Glaucoma Study Group
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Dec 3, 2014·American Journal of Ophthalmology·Phuc V LeUNKNOWN Advanced Imaging for Glaucoma Study Group

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Citations

Dec 3, 2015·American Journal of Ophthalmology·Xinbo ZhangUNKNOWN Advanced Imaging for Glaucoma Study Group
Jul 7, 2016·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Evan SilversteinMays El-Dairi
Feb 21, 2018·Journal of Glaucoma·Elham GhahariRobert N Weinreb
Sep 8, 2018·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Brad Fortune
Nov 17, 2015·Current Opinion in Ophthalmology·Jean-Claude Mwanza, Donald L Budenz
Jun 26, 2020·Journal of Current Glaucoma Practice·Hend SafwatAfaf Rashwan
Jun 11, 2021·Translational Vision Science & Technology·Ou TanDavid Huang
Jun 13, 2021·Eye·Khaldoon O Al-NosairyMichael Bach

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Software Mentioned

GSDI

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