Combining multivariate voxel selection and support vector machines for mapping and classification of fMRI spatial patterns

NeuroImage
Federico De MartinoElia Formisano

Abstract

In functional brain mapping, pattern recognition methods allow detecting multivoxel patterns of brain activation which are informative with respect to a subject's perceptual or cognitive state. The sensitivity of these methods, however, is greatly reduced when the proportion of voxels that convey the discriminative information is small compared to the total number of measured voxels. To reduce this dimensionality problem, previous studies employed univariate voxel selection or region-of-interest-based strategies as a preceding step to the application of machine learning algorithms. Here we employ a strategy for classifying functional imaging data based on a multivariate feature selection algorithm, Recursive Feature Elimination (RFE) that uses the training algorithm (support vector machine) recursively to eliminate irrelevant voxels and estimate informative spatial patterns. Generalization performances on test data increases while features/voxels are pruned based on their discrimination ability. In this article we evaluate RFE in terms of sensitivity of discriminative maps (Receiver Operative Characteristic analysis) and generalization performances and compare it to previously used univariate voxel selection strategies based on...Continue Reading

References

Mar 17, 1998·NeuroImage·K J FristonR Turner
Aug 19, 2000·Human Brain Mapping·M J FadiliB Mazoyer
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·J P Rauschecker, B Tian
Jan 27, 2005·NeuroImage·J D WarrenT D Griffiths
Apr 6, 2005·NeuroImage·Thomas NicholsJean-Baptiste Poline
Apr 15, 2005·Journal of Cognitive Neuroscience·Alice J O'TooleJames V Haxby
Apr 27, 2005·Nature Neuroscience·John-Dylan Haynes, Geraint Rees
Apr 27, 2005·Nature Neuroscience·Yukiyasu Kamitani, Frank Tong
May 24, 2005·NeuroImage·Stephen LaConteXiaoping Hu
May 27, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·James W LewisEdgar A DeYoe
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Nikolaus KriegeskortePeter Bandettini
Jun 23, 2006·Nature Reviews. Neuroscience·John-Dylan Haynes, Geraint Rees
Aug 11, 2006·Trends in Cognitive Sciences·Kenneth A NormanJames V Haxby
Feb 13, 2007·Current Biology : CB·John-Dylan HaynesRichard E Passingham
May 26, 2007·NeuroImage·Ze WangJohn A Detre

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Citations

May 29, 2012·European Archives of Psychiatry and Clinical Neuroscience·Dominik GrotegerdUdo Dannlowski
Aug 30, 2012·European Child & Adolescent Psychiatry·B A JohnstonJ D Steele
Sep 12, 2012·Brain Topography·Patrik AnderssonNick F Ramsey
Jul 27, 2010·Cell Biochemistry and Biophysics·Christian HabeckUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Feb 19, 2013·Neuroinformatics·J SchrouffJ Mourão-Miranda
Feb 14, 2012·Nature Neuroscience·Hiroshi BanAndrew E Welchman
Feb 25, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andre F MarquandMitul A Mehta
Jun 14, 2012·Cerebral Cortex·Adrian NestorDavid C Plaut
Sep 20, 2012·Cerebral Cortex·Andreas SchindlerAndreas Bartels
Mar 7, 2013·Cerebral Cortex·Stefano AnzellottiAlfonso Caramazza
Apr 12, 2013·Journal of Neurophysiology·Aidan P MurphyAndrew E Welchman
May 8, 2013·Journal of Cognitive Neuroscience·Dicle DövencioğluAndrew E Welchman
Sep 2, 2010·Neural Computation·Tanya SchmahStephen C Strother
Jul 9, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joonkoo ParkThad A Polk
Dec 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Fumiko HoeftJohn D E Gabrieli
Sep 10, 2013·Neuroinformatics·Benson MwangiJair C Soares
Feb 22, 2014·Medical Image Analysis·Emilio Parrado-HernándezCarles Soriano-Mas
Jun 18, 2009·Experimental Brain Research·Rainer Goebel, Nienke van Atteveldt
Mar 29, 2014·Neuroinformatics·Dominik GrotegerdUdo Dannlowski
Jun 24, 2014·Radiology·Frederik BarkhofSerge A R B Rombouts
Jan 26, 2011·Cognitive, Affective & Behavioral Neuroscience·Stephen JohnstonS G Boehm
Oct 9, 2015·NeuroImage. Clinical·Christian LambertHugh S Markus
Apr 6, 2016·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Benson MwangiJair C Soares

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