Combining nuchal translucency with umbilical Doppler velocimetry for detecting fetal trisomies in the first trimester of pregnancy

British Journal of Obstetrics and Gynaecology
J M MartínezA Fortuny

Abstract

The aim of our study was to evaluate whether the combined use of umbilical artery pulsatility index (UAPI) and nuchal translucency (NT) measurements would be useful in the prediction of fetal chromosomal abnormalities at 10 to 13 weeks of gestation. A prospective study. Five hundred and fifty-three consecutive women with singleton pregnancies between 10 and 13 weeks of gestation, who underwent chorionic villus sampling at our institution. UAPI and fetal NT thickness were measured immediately before the invasive procedure. Pregnancies in which structural malformations had been detected by ultrasound were excluded. Using the 95th centile and 3 mm as the cutoffs for UAPI and NT, respectively, the detection rate for all chromosomal anomalies was 84.2%, with a false positive rate (1-specificity) of 6.6%, a positive predictive value of 31.3%, and a negative predictive value of 99.4%. Out of the 553 tested pregnancies 502 had both parameters within the normal range and only three of them (0.6%) were chromosomally abnormal; in six of the eight cases (75%) in which both parameters were abnormal a chromosome anomaly was present. Of the 43 cases in which only one parameter was abnormal, 10 were chromosomally abnormal (23.2%). Our results ...Continue Reading

References

Dec 1, 1992·American Journal of Obstetrics and Gynecology·A DruganM I Evans
Feb 1, 1992·American Journal of Obstetrics and Gynecology·E JauniauxJ Hustin
Jul 1, 1990·Journal of Clinical Ultrasound : JCU·I StabileS Campbell
Apr 15, 1985·American Journal of Obstetrics and Gynecology·B R BenacerrafL A Laboda
May 1, 1995·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J M MartinezA Fortuny
Mar 1, 1995·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J SzabóG Szemere
Jan 1, 1995·American Journal of Obstetrics and Gynecology·P KuhnK H Nicolaides
Jan 1, 1995·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·C ComasA Fortuny
Sep 1, 1994·British Journal of Obstetrics and Gynaecology·K H NicolaidesR J Snijders
Apr 1, 1996·British Journal of Obstetrics and Gynaecology·J M Martinez CrespoA Fortuny
Jul 1, 1993·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·T W HuismanJ W Wladimiroff

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Citations

Dec 17, 1998·American Journal of Obstetrics and Gynecology·A BorrellA Fortuny
May 8, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·E AntolínJ M Carrera
Nov 18, 2003·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J M MartínezA Fortuny
Jul 12, 2005·Gynécologie, obstétrique & fertilité·P Rozenberg
Apr 9, 2015·Archives of Gynecology and Obstetrics·A FlöckAnnegret Geipel
Jul 30, 1999·British Journal of Obstetrics and Gynaecology·D L EconomidesJ M Braithwaite
Jun 26, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A Weissman, A Drugan
Mar 25, 2000·Journal of Perinatal Medicine·A Kurjak
Oct 18, 2003·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·F StipoljevA Kurjak
Feb 17, 2007·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Jiri Sonek
Sep 28, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Karampreet KaurLisa C Zuckerwise

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