Combining olfactory test and motion analysis sensors in Parkinson's disease preclinical diagnosis: a pilot study

Acta Neurologica Scandinavica
Carlo MaremmaniGiuseppe Meco

Abstract

Preclinical diagnosis of Parkinson's disease (PD) is nowadays a topic of interest as the neuropathological process could begin years before the appearance of motor symptoms. Several symptoms, among them hyposmia, could precede motor features in PD. In the preclinical phase of PD, a subclinical reduction in motor skills is highly likely. In this pilot study, we investigate a step-by-step method to achieve preclinical PD diagnosis. We used the IOIT (Italian Olfactory Identification Test) to screen a population of healthy subjects. We identified 20 subjects with idiopathic hyposmia. Hyposmic subjects underwent an evaluation of motor skills, at baseline and after 1 year, using motion analysis sensors previously created by us. One subject showed significant worsening in motor measurements. In this subject, we further conducted a dopaminergic challenge test monitored with the same sensors and, finally, he underwent [123 I]-FP/CIT (DaTscan) SPECT brain imaging. The results show that he is probably affected by preclinical PD. Our pilot study suggests that the combined use of an olfactory test and motor sensors for motion analysis could be useful for a screening of healthy subjects to identify those at a high risk of developing PD.

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Apr 11, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·A AlbaneseM Zappia
Aug 24, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Bart PostJohannes D Speelman
Jan 30, 2010·Parkinsonism & Related Disorders·Henk W Berendse, Mirthe M Ponsen
May 19, 2010·Nature Reviews. Neurology·Anthony H V Schapira, Eduardo Tolosa
Jul 10, 2010·Neuro-degenerative Diseases·Heinz Reichmann
Sep 14, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Walter MaetzlerBastiaan R Bloem
Nov 2, 2013·Perceptual and Motor Skills·Kerry A HubelDavid L Woods
Mar 13, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A GaenslenD Berg
Feb 11, 2015·Acta Neurologica Scandinavica·R K ChongC Wakade
Aug 9, 2015·Journal of Neural Transmission·Christiana OssigAlexander Storch
Oct 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Daniela BergGünther Deuschl
Oct 21, 2015·Journal of Parkinson's Disease·Philipp MahlknechtWerner Poewe
Nov 19, 2015·Parkinsonism & Related Disorders·Krisztina HorváthNorbert Kovács

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Citations

Jul 31, 2018·Acta Neurologica Scandinavica·Kristian Varden GjerdeOle-Bjørn Tysnes
Jul 22, 2018·Annals of Biomedical Engineering·Erika RoviniFilippo Cavallo
Jun 30, 2019·Brain and Behavior·Davide SattinUNKNOWN Coma Research Center, Fondazione IRCCS Istituto Neurologico “Carlo Besta”, Milan, Italy
Oct 3, 2020·Annals of Biomedical Engineering·Abdul Haleem ButtFilippo Cavallo

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