Combining PMTCT with active case finding for tuberculosis

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Paula B N KaliNeil A Martinson

Abstract

Tuberculosis (TB) is the preeminent manifestation of HIV infection and has become a leading cause of maternal mortality and morbidity in high HIV-prevalence settings. Active TB in pregnant women has potentially serious consequences for fetuses and newborns. In Soweto, South Africa, there is a more than 90% uptake of voluntary counseling and HIV testing during routine antenatal care, and almost one third of pregnant women are HIV-infected. The posttest counseling session of the prevention of mother-to-child transmission program provides an opportunity to screen HIV-infected pregnant women for TB. In this study, 370 HIV-infected pregnant women were screened for symptoms of active TB by lay counselors at the posttest counseling session. If symptomatic, they were referred to nurses who investigated them further. Eight women were found to have previously undiagnosed, smear-negative, culture-confirmed TB (2160/100,000). The mean CD4 count in those with active TB compared to those without TB was 276 x 10(6) cells per liter vs 447 x 10(6) cells per liter (P = 0.051). Symptoms most associated with active TB were hemoptysis and fever. We conclude that rates of TB in HIV-infected pregnant women are high, and screening for TB during routin...Continue Reading

Associated Clinical Trials

Citations

Jul 8, 2011·The New England Journal of Medicine·Neil A MartinsonRichard E Chaisson
Jun 21, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Amita GuptaUNKNOWN Byramjee Jeejeebhoy Medical College-Johns Hopkins University Study Group
Jun 21, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lynne M Mofenson, Barbara E Laughon
Sep 24, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Amita GuptaUNKNOWN Byramjee Jeejeebhoy Medical College–Johns Hopkins University Study Group
Sep 4, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jyoti S Mathad, Amita Gupta
Jan 7, 2011·The Journal of Infectious Diseases·Ben J Marais
Mar 26, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Celine R GounderNeil A Martinson
Oct 19, 2011·Journal of Pregnancy·Eleanor R TurnbullStewart E Reid
Jun 19, 2010·American Journal of Respiratory and Critical Care Medicine·Keren MiddelkoopRobin Wood
Jul 20, 2007·Bulletin of the World Health Organization·K F Laserson, C D Wells
Aug 4, 2009·Bulletin of the World Health Organization·A C HesselingP Godfrey-Faussett
Sep 12, 2014·Journal of Public Health Policy·Mercedes C Becerra, Soumya Swaminathan
Feb 11, 2016·BJOG : an International Journal of Obstetrics and Gynaecology·T E de JonghR Atun
Nov 20, 2014·BMC Infectious Diseases·Hang Thanh NguyenMaurizio Bonati
Jul 31, 2007·Vaccine·A C HesselingL Kuhn
Jan 26, 2011·Annals of Tropical Paediatrics·S BasuB K Das
Nov 19, 2010·BJOG : an International Journal of Obstetrics and Gynaecology·C N Mnyani, J A McIntyre
May 9, 2012·The Journal of Obstetrics and Gynaecology Research·Narayan JanaArun Kumarendu Singh
Dec 1, 2014·The Lancet Global Health·Jordan SugarmanOlivia Oxlade
Jul 10, 2007·Respiratory Medicine·Elsa PeyratBruno Degano
Jan 15, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Patricia L ToroAndrea A Howard
Jun 30, 2011·Drugs·Kartik K VenkateshKenneth H Mayer
Sep 4, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sylvia M LaCourseDavid J Horne
Aug 15, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Appolinaire TiamSeble Kassaye
Jul 28, 2016·Paediatrics and International Child Health·Khakhu Tshilidzi Mathivha, Sithembiso Velaphi
Aug 2, 2014·The Journal of Infectious Diseases·Kelly E DooleyUNKNOWN TSHEPISO Study Team

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.