Abstract
Improved prediction of progression to Alzheimer's Disease (AD) among older individuals with mild cognitive impairment (MCI) is of high clinical and societal importance. We recently developed a polygenic hazard score (PHS) that predicted age of AD onset above and beyond APOE. Here, we used data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to further explore the potential clinical utility of PHS for predicting AD development in older adults with MCI. We examined the predictive value of PHS alone and in combination with baseline structural magnetic resonance imaging (MRI) data on performance on the Mini-Mental State Exam (MMSE). In survival analyses, PHS significantly predicted time to progression from MCI to AD over 120 months (p = 1.07e-5), and PHS was significantly more predictive than APOE alone (p = 0.015). Combining PHS with baseline brain atrophy score and/or MMSE score significantly improved prediction compared to models without PHS (three-factor model p = 4.28e-17). Prediction model accuracies, sensitivities and area under the curve were also improved by including PHS in the model, compared to only using atrophy score and MMSE. Further, using linear mixed-effect modeling, PHS improved the prediction of chan...Continue Reading
References
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jun 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·C P HughesR L Martin
Dec 30, 2008·AJNR. American Journal of Neuroradiology·J B BrewerM E Smith
Feb 10, 2009·Radiology·Linda K McEvoyUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 29, 2009·Neurology·P VemuriUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 23, 2009·Behavioural Neurology·J B Brewer
Apr 8, 2011·Radiology·Linda K McEvoyUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 15, 2011·Neurology·D HeisterUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Dec 16, 2011·Cerebral Cortex·Mert R SabuncuUNKNOWN Alzheimer's Disease Neuroimaging Initiative
May 15, 2012·NeuroImage·Eric WestmanAndrew Simmons
Oct 20, 2012·PloS One·Dominic HollandUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Oct 8, 2013·Clinics in Geriatric Medicine·Rosebud Roberts, David S Knopman
Oct 29, 2013·Nature Genetics·J C LambertP Amouyel
Nov 19, 2013·PloS One·Perry G RidgeUNKNOWN Alzheimer’s Disease Genetics Consortium
May 14, 2014·Annual Review of Neuroscience·Jin-Tai YuJohn Hardy
Sep 10, 2014·Journal of Alzheimer's Disease : JAD·Carl EckerströmAnders Wallin
May 20, 2015·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·UNKNOWN Alzheimer’s Association
May 24, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·Jie-Qiong LiJin-Tai Yu
Nov 6, 2015·Alzheimer's Research & Therapy·Brandy L CallahanUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Nov 26, 2015·Journal of Alzheimer's Disease : JAD·Juergen DukartAlessandro Bertolino
Dec 20, 2015·The Lancet. Psychiatry·Craig W RitchieUNKNOWN European Prevention of Alzheimer's Dementia (EPAD) Consortium
Feb 23, 2017·Journal of Alzheimer's Disease : JAD·Riccardo E MarioniIan J Deary
Mar 23, 2017·PLoS Medicine·Rahul S DesikanAnders M Dale
Sep 25, 2017·Annals of Neurology·Chin Hong TanRahul S Desikan
Nov 28, 2017·Acta Neuropathologica·Chin Hong TanUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Citations
Jul 12, 2019·The British Journal of Radiology·Leo P Sugrue, Rahul S Desikan
Mar 15, 2019·Neurology·Lisa A Cannon-AlbrightJohn S K Kauwe
Dec 4, 2019·Topics in Magnetic Resonance Imaging : TMRI·Luke W BonhamJennifer S Yokoyama
Jan 29, 2019·Brain : a Journal of Neurology·Chin Hong TanUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Sep 5, 2020·GeroScience·María Eugenia LópezAlberto Fernández
Oct 18, 2018·The Journal of Comparative Neurology·G Allan JohnsonLeonard E White
Mar 15, 2019·International Journal of Molecular Sciences·Jialing FanZhanjun Zhang
Mar 7, 2019·Frontiers in Neuroinformatics·Artemis Zavaliangos-PetropuluPaul M Thompson
Jul 28, 2020·Translational Psychiatry·Karolina KauppiRolf Adolfsson
Dec 10, 2019·Brain Research·Jessica IzzoDennis van der Meer
Apr 16, 2021·Frontiers in Neuroscience·Xiaopu ZhouNancy Y Ip
Jun 3, 2020·Current Neuropharmacology·Sahil KhanMaushmi S Kumar
Jun 1, 2021·Frontiers in Neuroscience·Jiaqi ZhouChao Chen
Oct 8, 2020·Current Alzheimer Research·Matteo De Marco Alzheimer's Disease Neuroimaging Initiative
Aug 14, 2021·Circulation. Cardiovascular Imaging·Matthew NayorRamachandran S Vasan
Aug 28, 2021·Genes·Laura IbanezMaria Victoria Fernández
Sep 21, 2021·Frontiers in Aging Neuroscience·Kaicheng LiVince D Calhoun