PMID: 9451553Feb 6, 1998Paper

Combining QUANTICYT karyometric analysis with architectural confocal-aided cytology to prognosticate superficial bladder cancer

Diagnostic Cytopathology
M E BoonH G van der Poel

Abstract

For this study, bladder washings of 923 patients with a follow-up for superficial bladder cancer were used. For the prognostication of each case (follow-up period up to 20 mo), two parameters were used: tumor recurrence and the event of (progressing) invasive growth. Each sample was classified as negative, low grade or high grade, based on confocal-aided architectural cytology. The feature architecture was based on the images of the epithelial fragments as seen in the Feulgen stain, which also could be visualized in confocal microscopy. The same three classes were also used for grading the samples according to the QUANTICYT system, in which DNA and morphometry of nuclei were automatically assessed. The 532 cases graded as QUANTICYT high had a worse prognosis than the 391 cases with QUANTICYT low. In addition, architectural cytology contributed significantly for the prognostication of cases classified as QUANTICYT high, the 228 nonconcording cases faring better than the 304 concording ones. For QUANTICYT low, the 156 nonconcording cases had also a lower recurrence rate than the 235 concording ones, but this difference was only significant in patients followed for up to 8 mo. These findings indicate that QUANTICYT grading supplem...Continue Reading

References

Jan 1, 1992·Urological Research·H G van der PoelJ A Schalken
Jul 1, 1992·The Journal of Urology·H G van der PoelJ A Schalken
Sep 1, 1988·British Journal of Urology·P D AbelG Williams
Oct 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K H KurthW Oosterlinck

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Citations

Jan 11, 2001·Advances in Anatomic Pathology·J S Ross, M B Cohen
Sep 23, 2003·Current Opinion in Obstetrics & Gynecology·Sanaa EissaOmar El-Ahmady

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