Combining self-assembled monolayers and mass spectrometry for applications in biochips

Annual Review of Analytical Chemistry
Zachary A Gurard-Levin, Milan Mrksich

Abstract

Biochip arrays have enabled the massively parallel analysis of genomic DNA and hold great promise for application to the analysis of proteins, carbohydrates, and small molecules. Surface chemistry plays an intrinsic role in the preparation and analysis of biochips by providing functional groups for immobilization of ligands, providing an environment that maintains activity of the immobilized molecules, controlling nonspecific interactions of analytes with the surface, and enabling detection methods. This review describes recent advances in surface chemistry that enable quantitative assays of a broad range of biochemical activities. The discussion emphasizes the use of self-assembled monolayers of alkanethiolates on gold as a structurally well-defined and synthetically flexible platform for controlling the immobilization and activity of molecules in an array. The review also surveys recent methods of performing label-free assays, and emphasizes the use of matrix-assisted laser desorption/ionization mass spectrometry to directly observe molecules attached to the self-assembled monolayers.

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Citations

Oct 27, 2009·Nucleic Acids Research·Joohoon Kim, Milan Mrksich
Oct 30, 2009·Nucleic Acids Research·Kyu-Han KimKyu-Won Kim
Jun 5, 2012·Biomicrofluidics·Nick R GlassJames R Friend
Mar 5, 2011·Annual Review of Analytical Chemistry·Grant E JohnsonJulia Laskin
Jun 7, 2011·ACS Combinatorial Science·Zachary A Gurard-LevinMilan Mrksich
Dec 1, 2011·Angewandte Chemie·Che-Hsiung HsuChi-Huey Wong
Jan 13, 2011·Angewandte Chemie·Xiaoli LiaoMilan Mrksich
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Sep 9, 2010·Journal of the American Chemical Society·Shih-Huang ChangChi-Huey Wong
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Feb 21, 2019·Annual Review of Analytical Chemistry·Luke HanleyYeni P Yung
May 10, 2013·Organic & Biomolecular Chemistry·Carsten GraboschThisbe K Lindhorst
Apr 11, 2014·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Mi-Sun HaWoon-Seok Yeo
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Dec 20, 2012·ACS Applied Materials & Interfaces·Michael J RothSteven M Patrie
Jan 11, 2018·ACS Applied Materials & Interfaces·Inseong ChoiWoon-Seok Yeo
Nov 12, 2020·Journal of the American Chemical Society·Adam J PluchinskyMilan Mrksich

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Methods Mentioned

BETA
chips
chip
biosensor
irradiate
antibody array
fluorescence-imaging

Software Mentioned

SAMDI

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