PMID: 9164423Apr 1, 1997Paper

Combining serotonin reuptake inhibitors and bupropion in partial responders to antidepressant monotherapy

The Journal of Clinical Psychiatry
J A BodkinR J Baldessarini

Abstract

Many patients with affective illness show partial or otherwise unsatisfactory responses to standard treatments, encouraging trials of combinations of pharmacologically dissimilar antidepressants. Records of consecutive outpatients with affective disorders only partially responsive to treatment with a serotonin reuptake inhibitor (SRI) or bupropion, alone, were reviewed for changes in specific symptoms and risks of adverse events when an SRI and bupropion were combined. Greater symptomatic improvement was found in 19 (70%) of 27 subjects during a mean +/- SD of 11 +/- 14 months of combined daily use of bupropion (243 +/- 99 mg) with an SRI (31 +/- 16 mg fluoxetine-equivalents) than with either agent alone. Adverse effect risks were similar to those associated with each monotherapy, with a > 10% incidence of sexual dysfunction (N = 11, 41%), insomnia (N = 6, 22%), anergy (N = 4, 15%), and tremor (N = 3, 11%) during combined therapy; there were no seizures. With conservative dosing and close monitoring, combinations of SRIs with bupropion in this uncontrolled clinical series appeared to be safe and often more effective than monotherapy.

Associated Clinical Trials

Citations

Apr 26, 2006·Cellular and Molecular Neurobiology·Piotr PopikAnthony S Basile
Dec 2, 2005·Current Psychiatry Reports·Charles DeBattista, Anna Lembke
Jun 9, 2004·Journal of Affective Disorders·Gabriel RubioCecilio Alamo
Jan 13, 1999·Pediatric Clinics of North America·B BirmaherJ Renaud
Jul 10, 2002·Journal of Affective Disorders·S A MontgomeryA Riley
Mar 12, 2004·Journal of Affective Disorders·Andrew J TomarkenRichard C Shelton
Oct 4, 2008·Journal of Psychiatric Practice·Andrew F LeuchterJonathan W Stewart
Mar 5, 2011·Biological & Pharmaceutical Bulletin·Jillissa Christine MolnariAlan Lewis Myers
Jan 11, 2012·Annals of Family Medicine·David W MorrisMadhukar H Trivedi
Jul 14, 2011·Neuropsychiatric Disease and Treatment·Chantal Moret, Mike Briley
Jul 20, 2005·Primary Care Companion to the Journal of Clinical Psychiatry·Maurizio FavaJ Andrew Johnston
May 18, 2000·Clinical Therapeutics·L B Marangell
Jan 1, 1999·International Journal of Psychiatry in Clinical Practice·J Q BosticJ Biederman
Feb 21, 2007·Expert Opinion on Pharmacotherapy·Anita H Clayton
Sep 9, 2006·CNS Drug Reviews·Phil SkolnickArnold Lippa
Apr 1, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Reiji YoshimuraJun Nakamura
Mar 17, 2007·The Psychiatric Clinics of North America·Andrew A NierenbergMaurizio Fava
Nov 26, 2005·Acta Psychiatrica Scandinavica. Supplementum·J E RojoJ M de Pedro
May 21, 2013·Psychiatry and Clinical Neurosciences·Young Sup WooWon Kim
Feb 10, 2006·Behaviour Research and Therapy·Joseph A HimleGregory L Hanna
Mar 23, 2005·Journal of Affective Disorders·Gabriel S DichterRichard C Shelton
Sep 17, 2005·Biological Psychiatry·Sidney ZisookCarol B Rockett
Jan 18, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·George I Papakostas
Jan 9, 2001·The Psychiatric Clinics of North America·C M Dording
Mar 11, 2006·Depression and Anxiety·George I PapakostasMaurizio Fava
Jul 7, 2010·Neuroscience and Biobehavioral Reviews·Michael T Treadway, David H Zald
Aug 24, 2010·Behaviour Research and Therapy·Christina M GilliamDavid F Tolin
Sep 1, 2004·Expert Opinion on Drug Safety·David S Baldwin
Apr 19, 2016·Psychoneuroendocrinology·Jasmine Carter, Walter Swardfager
Sep 1, 2008·Psychiatry Investigation·David M MarksAshwin A Patkar
Sep 24, 2002·The Annals of Pharmacotherapy·Razmic S GregorianZeba M Khan
Mar 29, 2002·The Annals of Pharmacotherapy·Rajamannar Ramasubbu
Jul 20, 1999·The Annals of Pharmacotherapy·S H FatemiD A Kist
Oct 16, 2014·Journal of Psychopharmacology·Roger M Lane
Jan 17, 2017·Expert Review of Neurotherapeutics·Ricardo P GarayPierre-Michel Llorca

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.