Combining statistical shape modeling, CFD, and meta-modeling to approximate the patient-specific pressure-drop across the aortic valve in real-time.

International Journal for Numerical Methods in Biomedical Engineering
M J M M HoeijmakersF N van de Vosse

Abstract

Advances in medical imaging, segmentation techniques, and high performance computing have stimulated the use of complex, patient-specific, three-dimensional Computational Fluid Dynamics (CFD) simulations. Patient-specific, CFD-compatible geometries of the aortic valve are readily obtained. CFD can then be used to obtain the patient-specific pressure-flow relationship of the aortic valve. However, such CFD simulations are computationally expensive, and real-time alternatives are desired. The aim of this work is to evaluate the performance of a meta-model with respect to high-fidelity, three-dimensional CFD simulations of the aortic valve. Principal component analysis was used to build a statistical shape model (SSM) from a population of 74 iso-topological meshes of the aortic valve. Synthetic meshes were created with the SSM, and steady-state CFD simulations at flow-rates between 50 and 650 mL/s were performed to build a meta-model. The meta-model related the statistical shape variance, and flow-rate to the pressure-drop. Even though the first three shape modes account for only 46% of shape variance, the features relevant for the pressure-drop seem to be captured. The three-mode shape-model approximates the pressure-drop with an...Continue Reading

References

Dec 18, 2002·Journal of Biomechanics·J De HartF P T Baaijens
Sep 6, 2005·Journal of Biomechanics·Theodosios Korakianitis, Yubing Shi
Aug 30, 2008·IEEE Transactions on Medical Imaging·Olivier EcabertJürgen Weese
Apr 30, 2009·Annual Review of Biomedical Engineering·C A Taylor, C A Figueroa
Jun 16, 2009·Medical Image Analysis·Tobias Heimann, Hans-Peter Meinzer
Dec 4, 2009·Briefings in Bioinformatics·Maxwell Lewis Neal, Roy Kerckhoffs
May 6, 2010·IEEE Transactions on Medical Imaging·Razvan Ioan IonasecDorin Comaniciu
Mar 2, 2011·Computer Methods in Biomechanics and Biomedical Engineering·Daniel P Nicolella, Todd L Bredbenner
Jul 9, 2011·Medical Image Analysis·Olivier EcabertJürgen Weese
Oct 15, 2011·Artificial Organs·Christian VergaraGiovanni Battista Luciani
Sep 4, 2012·International Journal for Numerical Methods in Biomedical Engineering·Matteo AstorinoJean-Frédéric Gerbeau
Oct 30, 2015·Heart·Paul D MorrisJulian P Gunn
Nov 27, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Sandra LoerakkerFrank P T Baaijens
Jun 2, 2016·BMC Medical Imaging·Jan L BruseUNKNOWN Modeling of Congenital Hearts Alliance (MOCHA) Collaborative Group
Jun 22, 2016·International Journal for Numerical Methods in Biomedical Engineering·Kewei Li, Wei Sun
Aug 27, 2016·Biomedical Engineering Online·Siamak N DoostYosry S Morsi
Sep 27, 2016·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·E M J van DisseldorpR G P Lopata
Jan 20, 2017·IEEE Journal of Biomedical and Health Informatics·Avan SuinesiaputraPau Medrano-Gracia
Feb 14, 2017·The Journal of Thoracic and Cardiovascular Surgery·Naoyuki KimuraKoji Kawahito
Mar 10, 2017·BMC Medical Imaging·Sebastian F BaumbachLukas Fischer
Oct 31, 2017·International Journal of Computer Assisted Radiology and Surgery·Marc Anton FuessingerStefan Schlager
Nov 10, 2017·International Journal for Numerical Methods in Biomedical Engineering·Fei XuMing-Chen Hsu
May 31, 2018·Biomedical Engineering Online·Dominik Spinczyk, Agata Krasoń
Jun 21, 2018·Annals of Biomedical Engineering·Zhigang LiXinfeng Han
Jul 31, 2019·Journal of Biomechanics·M J M M HoeijmakersF N van de Vosse

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Citations

Feb 10, 2021·Journal of the Royal Society, Interface·Amirhossein Arzani, Scott T M Dawson

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

ANSYS DesignXplorer
PPS
EurValve
OS
ANSYS Fluent
ANSYS Fluent Meshing

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