Combining stereotactic body radiation therapy with immunotherapy: current data and future directions

Translational Lung Cancer Research
Alexander J LinClifford Robinson

Abstract

Stereotactic body radiation therapy (SBRT) offers excellent local control of early-stage non-small cell lung cancer (NSCLC), but there currently is a need for tolerable systemic therapy to address regional and distant disease progression. One potential option is immunotherapy, which in metastatic NSCLC has shown promise for sustained disease control in a subset of patients. There is also growing evidence for a clinical synergy between radiation and immunotherapy, with several ongoing trials studying the abscopal effect. This review summarizes the current data in the fast-changing field of immuno-radiation therapy, highlighting updates from recent clinical trials.

Citations

Mar 1, 2020·Molecular Oncology·Michele MondiniEric Deutsch
Jun 11, 2020·F1000Research·Isacco DesideriLorenzo Livi
Mar 7, 2020·Journal of the Chinese Medical Association : JCMA·Yuh-Min Chen
Oct 9, 2019·Nature Reviews. Clinical Oncology·Oliver KeppGuido Kroemer
Feb 20, 2021·Frontiers in Oncology·Juliane Hörner-RieberMarcel Verheij
Mar 12, 2021·Seminars in Thoracic and Cardiovascular Surgery·Mary McGunigalPuja Gaur Khaitan

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